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Table 3 Test accuracy for detection of colorectal cancer based on all possible gene combinations

From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Gene combination Counts Sensitivity % (95% CI) Specificity % (95% CI) AUC (95% CI) LRP (95% CI)
TP TN
BCAT1 only 87 776 47.3
(40.2–54.5)
94.6
(92.9–96.0)
0.710
(0.662–0.757)
8.8
(6.4–12.2)
IRF4 only 92 802 50.0
(42.8–57.2)
97.8
(96.6–98.6)
0.739
(0.691–0.787)
22.8
(14.1–36.8)
IKZF1 only 109 785 59.2
(52.0–66.1)
95.7
(94.1–96.9)
0.775
(0.730–0.820)
13.9
(9.8–19.6)
BCAT1 and-or IRF4 110 761 59.8
(52.6–66.6)
92.8
(90.8–94.4)
0.763
(0.718–0.808)
8.31
(6.3–10.9)
IKZF1 and-or IRF4 128 773 69.6
(62.6–75.8)
94.3
(92.5–95.7)
0.819
(0.778–0.860)
12.1
(9.1–16.3)
BCAT1 and-or IKZF1 129 750 70.1
(63.1–76.3)
91.5
(89.4–93.2)
0.808
(0.767–0.849)
8.21
(6.4–10.5)
Any of the 3 genes 136 739 73.9
(67.1–79.7)
90.1
(87.9–92.0)
0.820
(0.781–0.859)
7.48
(6.0–9.4)
  1. The true- and false-positive rates in cases with cancer (n = 184) and cases without neoplasia (n = 820) were used for sensitivity (for cancer) and specificity (for neoplasia) estimates
  2. TP Counts of true positives, TN Counts of true negatives, AUC area under the curve of ROC plots shown in Fig. 5, LRP positive likelihood ratio
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