Table 3 Test accuracy for detection of colorectal cancer based on all possible gene combinations
| Gene combination | Counts | Sensitivity % (95% CI) | Specificity % (95% CI) | AUC (95% CI) | LRP (95% CI) | |
|---|---|---|---|---|---|---|
| TP | TN | |||||
| BCAT1 only | 87 | 776 |
47.3 (40.2–54.5) |
94.6 (92.9–96.0) |
0.710 (0.662–0.757) |
8.8 (6.4–12.2) |
| IRF4 only | 92 | 802 |
50.0 (42.8–57.2) |
97.8 (96.6–98.6) |
0.739 (0.691–0.787) |
22.8 (14.1–36.8) |
| IKZF1 only | 109 | 785 |
59.2 (52.0–66.1) |
95.7 (94.1–96.9) |
0.775 (0.730–0.820) |
13.9 (9.8–19.6) |
| BCAT1 and-or IRF4 | 110 | 761 |
59.8 (52.6–66.6) |
92.8 (90.8–94.4) |
0.763 (0.718–0.808) |
8.31 (6.3–10.9) |
| IKZF1 and-or IRF4 | 128 | 773 |
69.6 (62.6–75.8) |
94.3 (92.5–95.7) |
0.819 (0.778–0.860) |
12.1 (9.1–16.3) |
| BCAT1 and-or IKZF1 | 129 | 750 |
70.1 (63.1–76.3) |
91.5 (89.4–93.2) |
0.808 (0.767–0.849) |
8.21 (6.4–10.5) |
| Any of the 3 genes | 136 | 739 |
73.9 (67.1–79.7) |
90.1 (87.9–92.0) |
0.820 (0.781–0.859) |
7.48 (6.0–9.4) |