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Table 3 Test accuracy for detection of colorectal cancer based on all possible gene combinations

From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Gene combination

Counts

Sensitivity % (95% CI)

Specificity % (95% CI)

AUC (95% CI)

LRP (95% CI)

TP

TN

BCAT1 only

87

776

47.3

(40.2–54.5)

94.6

(92.9–96.0)

0.710

(0.662–0.757)

8.8

(6.4–12.2)

IRF4 only

92

802

50.0

(42.8–57.2)

97.8

(96.6–98.6)

0.739

(0.691–0.787)

22.8

(14.1–36.8)

IKZF1 only

109

785

59.2

(52.0–66.1)

95.7

(94.1–96.9)

0.775

(0.730–0.820)

13.9

(9.8–19.6)

BCAT1 and-or IRF4

110

761

59.8

(52.6–66.6)

92.8

(90.8–94.4)

0.763

(0.718–0.808)

8.31

(6.3–10.9)

IKZF1 and-or IRF4

128

773

69.6

(62.6–75.8)

94.3

(92.5–95.7)

0.819

(0.778–0.860)

12.1

(9.1–16.3)

BCAT1 and-or IKZF1

129

750

70.1

(63.1–76.3)

91.5

(89.4–93.2)

0.808

(0.767–0.849)

8.21

(6.4–10.5)

Any of the 3 genes

136

739

73.9

(67.1–79.7)

90.1

(87.9–92.0)

0.820

(0.781–0.859)

7.48

(6.0–9.4)

  1. The true- and false-positive rates in cases with cancer (n = 184) and cases without neoplasia (n = 820) were used for sensitivity (for cancer) and specificity (for neoplasia) estimates
  2. TP Counts of true positives, TN Counts of true negatives, AUC area under the curve of ROC plots shown in Fig. 5, LRP positive likelihood ratio