Skip to main content

Table 1 Demographic characteristics and clinical findings by collection site

From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

 

N (%)

AUS

DEN

NLD

RUS

n (%)

Cases

1620 (100)

643 (39.7)

774 (47.8)

101 (6.2)

102 (6.3)

 Males

902 (55.7)

367 (57.1)

435 (56.2)

59 (58.4)

41 (40.2)a

 Median age (min–max)

63.0 years (18.1–88.0)

62.6 years (18.1–85.4)

64.3 years (50.0–75.8)

62.0 years (37.0–88.0)

56.5 yearsa (34.0–86.0)

Cancer

184 (11.4)

27 (14.7)

91 (49.5)

17 (9.2)

49 (26.6)

 Males

97 (52.7)

14 (51.9)

52 (57.1)

10 (58.8)

21 (42.9)

 Median age (min–max)

67.2 years (35.0–88.0)

66.2 years (45.7–81.1)

68.7 years (50.1–75.2)

70.0 years (37.0–88.0)

62.0 yearsa (35.0–86.0)

 Stage I

41 (22)

7 (17.1)

20 (48.8)

3 (7.3)

11 (26.8)

 Stage II

57 (31)

9 (15.8)

20 (35.1)

7 (12.3)

21 (36.8)

 Stage III

51 (28)

5 (9.8)

35 (68.6)

4 (7.8)

7 (13.7)

 Stage IV

33 (18)

6 (18.2)

16 (48.5)

3 (9.1)

8 (24.2)

 Unstaged

2 (1%)

0 (–)

0 (–)

0 (–)

2 (100)

Adenoma

616 (38.0)

332 (53.9)

197 (32.0)

52 (8.4)

35 (5.7)

 Males

387 (62.8)

207 (62.3)

131 (66.5)

33 (63.5)

16 (45.7)a

 Median age (min–max)

63.5 years (33.7–85.4)

64.1 years (33.7–85.4)

64.1 years (50.0–75.8)

62.4 years (51.0–75.0)

56.1 yearsa (34.0–82.0)

 Advanced

337 (54.7)

147 (44.3)

149 (75.6)

38 (73.1)

3 (8.6)

 Non-advanced

279 (45.3)

185 (55.7)

48 (24.4)

14 (26.9)

32 (91.4)

 HGDb

35 (5.7)

15 (4.5)

18 (9.1)

2 (3.8)

0 (0)

 LGDb

549 (89.1)

317 (95.5)

179 (90.9)

18 (34.6)

35 (100)

No neoplasia

820 (50.6%)

284 (34.6)

486 (59.3)

32 (3.9)

18 (2.2)

 Males

418 (51.0)

146 (51.4)

252 (51.9)

16 (50.0)

4 (22.2)a

 Median age (min–max)

60.0 years (18.0–85.0)

56.7 years (18.0–85.0)

62.2 years (50.0–75.0)

61.6 years (52.0–75.0)

47.5 yearsa (36.0–59.0)

  1. AUS, Flinders Medical Centre, Australia; DEN, Hvidovre Hospital, Denmark; NLD, Amsterdam University Medical Centers or Flevo Hospital, The Netherlands; RUS, Proteogenex
  2. aChi square, collection site significantly different from the other sites
  3. bThe severity of dysplasia was available for 584 of 616 adenomas. HGD high grade dysplasia, LGD low grade dysplasia