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Table 1 Demographic characteristics and clinical findings by collection site

From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

  N (%) AUS DEN NLD RUS
n (%)
Cases 1620 (100) 643 (39.7) 774 (47.8) 101 (6.2) 102 (6.3)
 Males 902 (55.7) 367 (57.1) 435 (56.2) 59 (58.4) 41 (40.2)a
 Median age (min–max) 63.0 years (18.1–88.0) 62.6 years (18.1–85.4) 64.3 years (50.0–75.8) 62.0 years (37.0–88.0) 56.5 yearsa (34.0–86.0)
Cancer 184 (11.4) 27 (14.7) 91 (49.5) 17 (9.2) 49 (26.6)
 Males 97 (52.7) 14 (51.9) 52 (57.1) 10 (58.8) 21 (42.9)
 Median age (min–max) 67.2 years (35.0–88.0) 66.2 years (45.7–81.1) 68.7 years (50.1–75.2) 70.0 years (37.0–88.0) 62.0 yearsa (35.0–86.0)
 Stage I 41 (22) 7 (17.1) 20 (48.8) 3 (7.3) 11 (26.8)
 Stage II 57 (31) 9 (15.8) 20 (35.1) 7 (12.3) 21 (36.8)
 Stage III 51 (28) 5 (9.8) 35 (68.6) 4 (7.8) 7 (13.7)
 Stage IV 33 (18) 6 (18.2) 16 (48.5) 3 (9.1) 8 (24.2)
 Unstaged 2 (1%) 0 (–) 0 (–) 0 (–) 2 (100)
Adenoma 616 (38.0) 332 (53.9) 197 (32.0) 52 (8.4) 35 (5.7)
 Males 387 (62.8) 207 (62.3) 131 (66.5) 33 (63.5) 16 (45.7)a
 Median age (min–max) 63.5 years (33.7–85.4) 64.1 years (33.7–85.4) 64.1 years (50.0–75.8) 62.4 years (51.0–75.0) 56.1 yearsa (34.0–82.0)
 Advanced 337 (54.7) 147 (44.3) 149 (75.6) 38 (73.1) 3 (8.6)
 Non-advanced 279 (45.3) 185 (55.7) 48 (24.4) 14 (26.9) 32 (91.4)
 HGDb 35 (5.7) 15 (4.5) 18 (9.1) 2 (3.8) 0 (0)
 LGDb 549 (89.1) 317 (95.5) 179 (90.9) 18 (34.6) 35 (100)
No neoplasia 820 (50.6%) 284 (34.6) 486 (59.3) 32 (3.9) 18 (2.2)
 Males 418 (51.0) 146 (51.4) 252 (51.9) 16 (50.0) 4 (22.2)a
 Median age (min–max) 60.0 years (18.0–85.0) 56.7 years (18.0–85.0) 62.2 years (50.0–75.0) 61.6 years (52.0–75.0) 47.5 yearsa (36.0–59.0)
  1. AUS, Flinders Medical Centre, Australia; DEN, Hvidovre Hospital, Denmark; NLD, Amsterdam University Medical Centers or Flevo Hospital, The Netherlands; RUS, Proteogenex
  2. aChi square, collection site significantly different from the other sites
  3. bThe severity of dysplasia was available for 584 of 616 adenomas. HGD high grade dysplasia, LGD low grade dysplasia
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