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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer

Fig. 2

Positivity by progression of cellular atypia (dysplasia in adenomas) and degree of invasion (T stage in cancer), in cases without disseminated disease. LGD low grade dysplasia, HGD high grade dysplasia. Y axis: average detection rates, % (sensitivity). Closed black circles—at least one PCR replicate positive for methylation in any of the three genes; blue, red and black symbols—detection rates of the individual methylation markers, IRF4, IKZF1 and BCAT1, respectively. Additional file 1: Table S1 provides details for count of positives, % detected and 95% CI. *Only 53 of the 57 Stage II cases had full TNM information

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