Male obesity impacts DNA methylation reprogramming in sperm

Clinical Epigenetics

Table 2 Top 20 differentially methylated CpG probes

CG probe ID	Nearest UCSC RefGene name	Chr	Avg β normal weight	Avg β overweight obese	Unadjusted p	Adjusted p
cg24769403	ADRA1B	5	0.021	0.119	2.43E−08	0.007
cg19350020	PHLDB1	11	0.930	0.883	7.09E−07	0.077
cg13985597	RP11-390F4.10	9	0.053	0.077	1.06E−06	0.077
cg10578952	TBCE	1	0.935	0.919	1.06E−06	0.077
cg07425780	GPRC5B	16	0.056	0.080	1.64E−06	0.096
cg04863514	FLCN	17	0.920	0.898	3.83E−06	0.186
cg14375912	COL12A1	6	0.051	0.067	5.93E−06	0.239
cg04147990	PRSS23	11	0.911	0.881	6.59E−06	0.239
cg02371408	VCAN	5	0.070	0.089	7.72E−06	0.239
cg02647408	GRM5	11	0.067	0.058	8.58E−06	0.239
cg16491274	FBXO42	1	0.032	0.043	9.03E−06	0.239
cg00931944	AF067845.1	8	0.846	0.812	9.97E−06	0.242
cg06960881	PMP22	17	0.867	0.878	1.11E−05	0.249
cg23072973	C11orf49	11	0.817	0.800	2.01E−05	0.395
cg15444472	CTD-2526M8.3	18	0.900	0.909	2.04E−05	0.395
cg18566911	PTPRN2	7	0.885	0.877	2.38E−05	0.403
cg15319585	SDK1	7	0.897	0.914	2.43E−05	0.403
cg11670605	PLCXD3	5	0.019	0.016	2.49E−05	0.403
cg04712949	CALCR	7	0.061	0.056	2.90E−05	0.445
cg13762612	RP11-390F4.10	9	0.078	0.110	3.30E−05	0.480

ISSN: 1868-7083