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Table 2 ToppFun top 5 enriched functional terms by tissue, significant with Bonferroni-corrected p values < 0.05

From: Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

Tissue GO: Molecular function GO: Biological process GO: Cellular component Mouse phenotype Disease
F1 Hippocampus 1. Metal ion transmembrane transporter activity (GO:0046873) 1. Neurogenesis (GO:0022008) 1. Synapse (GO:0045202) 1. Abnormal synaptic transmission (MP:0003635) 1. Neurodevelopmental disorders (C1535926)
  2. Cation channel activity (GO:0005261) 2. Generation of neuron (GO:0048699) 2. Neuron projection (GO:0043005) 2. Abnormal brain morphology (MP:0002152) 2. Intellectual disability (C3714756)
  3. Ion channel activity (GO:0005216) 3. Neuron differentiation (GO:0030182) 3. Cell junction (GO:0030054) 3. Abnormal CNS synaptic transmission (MP:0002206) 3. Epilepsy (C0014544)
  4. Cation transmembrane transporter activity (GO:0008324) 4. Neuron development (GO:0048666) 4. Somatodendritic compartment (GO:0036477) 4. Abnormal neuron morphology (MP:0002882) 4. Autistic disorder (C0004352)
  5. Inorganic cation transmembrane transporter activity (GO:0022890) 5. Cell–cell signaling (GO:0007267) 5. Synaptic membrane (GO:0097060) 5. Abnormal lymphatic vessel endothelium morphology (MP:0010195) 5. Global developmental delay (C0557874)
F1 Cortex 1. Actin binding (GO:0003779) 1. Cell morphogenesis (GO:0000902) 1. Synapse (GO:0045202) 1. Abnormal CNS synaptic transmission (MP:0002206) 1. Intellectual disability (C3714756)
  2. Cytoskeletal protein binding (GO:0008092) 2. Neurogenesis (GO:0022008) 2. Synaptic membrane (GO:0097060) 2. Abnormal synaptic transmission (MP:0003635) 2. Neurodevelopmental disorders (C1535926)
  3. Regulatory region nucleic acid binding (GO:0001067) 3. Cellular component morphogenesis (GO:0032989) 3. Neuron projection (GO:0043005)   3. Global developmental delay (C0557874)
  4. Channel activity (GO:0015267) 4. Neuron differentiation (GO:0030182) 4. Postsynapse (GO:0098794)   4. Developmental delay (disorder) (C0424605)
  5. Passive transmembrane transporter activity (GO:0022803) 5. Generation of neurons (GO:0048699) 5. Postsynaptic density (GO:0014069)   5. Congenital abnormality (C0000768)
F0 Cortex 1. Channel activity (GO:0015267) 1. Neurogenesis (GO:0022008) 1. Neuron projection (GO:0043005) 1. Abnormal CNS synaptic transmission (MP:0002206) 1. Intellectual disability (C3714756)
  2. Passive transmembrane transporter activity (GO:002280) 2. Generation of neurons (GO:0048699) 2. Synapse (GO:0045202) 2. Abnormal synaptic transmission (MP:0003635) 2. Epilepsy (C0014544)
  3. Ion channel activity (GO:0005216) 3. Cellular component morphogenesis (GO:0032989) 3. Postsynapse (GO:0098794) 3. Abnormal locomotor behavior (MP:0001392) 3. Autistic disorder (C0004352)
  4. Ion transmembrane transporter activity (GO:0015075) 4. Cell morphogenesis (GO:0000902) 4. Somatodendritic compartment (GO:0036477) 4. Abnormal brain morphology (MP:0002152) 4. Neurodevelopmental disorders (C1535926)
  5. Cation channel activity (GO:0005261) 5. Neuron differentiation (GO:0030182) 5. Cell junction (GO:0030054) 5. Abnormal locomotor activation (MP:0003313) 5. Bipolar disorder (C0005586)