Tissue | GO: Molecular function | GO: Biological process | GO: Cellular component | Mouse phenotype | Disease |
---|---|---|---|---|---|
F1 Hippocampus | 1. Metal ion transmembrane transporter activity (GO:0046873) | 1. Neurogenesis (GO:0022008) | 1. Synapse (GO:0045202) | 1. Abnormal synaptic transmission (MP:0003635) | 1. Neurodevelopmental disorders (C1535926) |
 | 2. Cation channel activity (GO:0005261) | 2. Generation of neuron (GO:0048699) | 2. Neuron projection (GO:0043005) | 2. Abnormal brain morphology (MP:0002152) | 2. Intellectual disability (C3714756) |
 | 3. Ion channel activity (GO:0005216) | 3. Neuron differentiation (GO:0030182) | 3. Cell junction (GO:0030054) | 3. Abnormal CNS synaptic transmission (MP:0002206) | 3. Epilepsy (C0014544) |
 | 4. Cation transmembrane transporter activity (GO:0008324) | 4. Neuron development (GO:0048666) | 4. Somatodendritic compartment (GO:0036477) | 4. Abnormal neuron morphology (MP:0002882) | 4. Autistic disorder (C0004352) |
 | 5. Inorganic cation transmembrane transporter activity (GO:0022890) | 5. Cell–cell signaling (GO:0007267) | 5. Synaptic membrane (GO:0097060) | 5. Abnormal lymphatic vessel endothelium morphology (MP:0010195) | 5. Global developmental delay (C0557874) |
F1 Cortex | 1. Actin binding (GO:0003779) | 1. Cell morphogenesis (GO:0000902) | 1. Synapse (GO:0045202) | 1. Abnormal CNS synaptic transmission (MP:0002206) | 1. Intellectual disability (C3714756) |
 | 2. Cytoskeletal protein binding (GO:0008092) | 2. Neurogenesis (GO:0022008) | 2. Synaptic membrane (GO:0097060) | 2. Abnormal synaptic transmission (MP:0003635) | 2. Neurodevelopmental disorders (C1535926) |
 | 3. Regulatory region nucleic acid binding (GO:0001067) | 3. Cellular component morphogenesis (GO:0032989) | 3. Neuron projection (GO:0043005) |  | 3. Global developmental delay (C0557874) |
 | 4. Channel activity (GO:0015267) | 4. Neuron differentiation (GO:0030182) | 4. Postsynapse (GO:0098794) |  | 4. Developmental delay (disorder) (C0424605) |
 | 5. Passive transmembrane transporter activity (GO:0022803) | 5. Generation of neurons (GO:0048699) | 5. Postsynaptic density (GO:0014069) |  | 5. Congenital abnormality (C0000768) |
F0 Cortex | 1. Channel activity (GO:0015267) | 1. Neurogenesis (GO:0022008) | 1. Neuron projection (GO:0043005) | 1. Abnormal CNS synaptic transmission (MP:0002206) | 1. Intellectual disability (C3714756) |
 | 2. Passive transmembrane transporter activity (GO:002280) | 2. Generation of neurons (GO:0048699) | 2. Synapse (GO:0045202) | 2. Abnormal synaptic transmission (MP:0003635) | 2. Epilepsy (C0014544) |
 | 3. Ion channel activity (GO:0005216) | 3. Cellular component morphogenesis (GO:0032989) | 3. Postsynapse (GO:0098794) | 3. Abnormal locomotor behavior (MP:0001392) | 3. Autistic disorder (C0004352) |
 | 4. Ion transmembrane transporter activity (GO:0015075) | 4. Cell morphogenesis (GO:0000902) | 4. Somatodendritic compartment (GO:0036477) | 4. Abnormal brain morphology (MP:0002152) | 4. Neurodevelopmental disorders (C1535926) |
 | 5. Cation channel activity (GO:0005261) | 5. Neuron differentiation (GO:0030182) | 5. Cell junction (GO:0030054) | 5. Abnormal locomotor activation (MP:0003313) | 5. Bipolar disorder (C0005586) |