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Table 2 ToppFun top 5 enriched functional terms by tissue, significant with Bonferroni-corrected p values < 0.05

From: Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

Tissue

GO: Molecular function

GO: Biological process

GO: Cellular component

Mouse phenotype

Disease

F1 Hippocampus

1. Metal ion transmembrane transporter activity (GO:0046873)

1. Neurogenesis (GO:0022008)

1. Synapse (GO:0045202)

1. Abnormal synaptic transmission (MP:0003635)

1. Neurodevelopmental disorders (C1535926)

 

2. Cation channel activity (GO:0005261)

2. Generation of neuron (GO:0048699)

2. Neuron projection (GO:0043005)

2. Abnormal brain morphology (MP:0002152)

2. Intellectual disability (C3714756)

 

3. Ion channel activity (GO:0005216)

3. Neuron differentiation (GO:0030182)

3. Cell junction (GO:0030054)

3. Abnormal CNS synaptic transmission (MP:0002206)

3. Epilepsy (C0014544)

 

4. Cation transmembrane transporter activity (GO:0008324)

4. Neuron development (GO:0048666)

4. Somatodendritic compartment (GO:0036477)

4. Abnormal neuron morphology (MP:0002882)

4. Autistic disorder (C0004352)

 

5. Inorganic cation transmembrane transporter activity (GO:0022890)

5. Cell–cell signaling (GO:0007267)

5. Synaptic membrane (GO:0097060)

5. Abnormal lymphatic vessel endothelium morphology (MP:0010195)

5. Global developmental delay (C0557874)

F1 Cortex

1. Actin binding (GO:0003779)

1. Cell morphogenesis (GO:0000902)

1. Synapse (GO:0045202)

1. Abnormal CNS synaptic transmission (MP:0002206)

1. Intellectual disability (C3714756)

 

2. Cytoskeletal protein binding (GO:0008092)

2. Neurogenesis (GO:0022008)

2. Synaptic membrane (GO:0097060)

2. Abnormal synaptic transmission (MP:0003635)

2. Neurodevelopmental disorders (C1535926)

 

3. Regulatory region nucleic acid binding (GO:0001067)

3. Cellular component morphogenesis (GO:0032989)

3. Neuron projection (GO:0043005)

 

3. Global developmental delay (C0557874)

 

4. Channel activity (GO:0015267)

4. Neuron differentiation (GO:0030182)

4. Postsynapse (GO:0098794)

 

4. Developmental delay (disorder) (C0424605)

 

5. Passive transmembrane transporter activity (GO:0022803)

5. Generation of neurons (GO:0048699)

5. Postsynaptic density (GO:0014069)

 

5. Congenital abnormality (C0000768)

F0 Cortex

1. Channel activity (GO:0015267)

1. Neurogenesis (GO:0022008)

1. Neuron projection (GO:0043005)

1. Abnormal CNS synaptic transmission (MP:0002206)

1. Intellectual disability (C3714756)

 

2. Passive transmembrane transporter activity (GO:002280)

2. Generation of neurons (GO:0048699)

2. Synapse (GO:0045202)

2. Abnormal synaptic transmission (MP:0003635)

2. Epilepsy (C0014544)

 

3. Ion channel activity (GO:0005216)

3. Cellular component morphogenesis (GO:0032989)

3. Postsynapse (GO:0098794)

3. Abnormal locomotor behavior (MP:0001392)

3. Autistic disorder (C0004352)

 

4. Ion transmembrane transporter activity (GO:0015075)

4. Cell morphogenesis (GO:0000902)

4. Somatodendritic compartment (GO:0036477)

4. Abnormal brain morphology (MP:0002152)

4. Neurodevelopmental disorders (C1535926)

 

5. Cation channel activity (GO:0005261)

5. Neuron differentiation (GO:0030182)

5. Cell junction (GO:0030054)

5. Abnormal locomotor activation (MP:0003313)

5. Bipolar disorder (C0005586)