Skip to main content

Table 4 DMRs for lung function trajectory in relation to childhood DNA-M identified by DMRcate method

From: Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

Lung function trajectory

Molecular location of the DMR (chromosome: start–end)

Annotated Genes

No. CpGs in the regionb

Stouffer

Males

 FVC

 

chr6: 110011156–110011999

FIG4, AK9

2

1.15 × 10–177

 

chr13: 112986154–112986635

LINC01044

4

9.26 × 10–143

 

chr11: 113660695–113660756

ATF4P4, RP11-667M19.5

2

1.13 × 10–113

 

chr1: 46859774–46859791

FAAH

2

3.51 × 10–65

 FEV1

 

chr17: 28928406–28928453

SMURF2P1

2

1.24 × 10–243

 

chr2: 172974138–172974630

DLX2a

2

1.14 × 10–175

 

chr16: 31147044–31147177

PRSS8

2

1.67 × 10–55

 

chr13: 37249426–37249450

SERTM1

2

1.78 × 10–48

 

chr6: 31148383–31148552

POU5F1

6

3.27 × 10–42

 

chr6: 74009041–74009455

KHDC1a

2

4.35 × 10–14

 FEV1/FVC

 

chr2: 20424423–20425395

SDC1

2

1.03 × 10–280

 

chr16: 84029457–84029584

NECAB2a

2

4.14 × 10–235

 

chr22: 39713008–39713062

RPL3

2

1.07 × 10–140

 

chr5: 177366867–177367013

RP11-1252I4.2

2

1.38 × 10–100

 

chr1: 47656137–47656140

PDZK1IP1

2

3.78 × 10–100

 

chr1: 223899845–223899998

CAPN2

2

1.41 × 10–95

 

chr7: 1003645–1004748

COX19a

3

3.69 × 10–79

 

chr6: 31846996–31847009

SLC44A4

2

3.88 × 10–43

 

chr1: 11761078–11761296

DRAXINa

2

3.60 × 10–29

 

chr5: 23951555–23951696

C5orf17

2

8.99 × 10–26

 

chr17: 78865368–78865662

RPTORa

2

1.76 × 10–15

 

chr15: 99409360–99409506

NA

2

1.12 × 10–12

 

chr2: 65593908–65594021

SPRED2

2

1.99 × 10–7

Females

 FVC

chr1: 1022530–1022900

C1orf159

2

1.51 × 10–139

 

chr11: 68621969–68622177

CPT1Aa

2

3.25 × 10–133

 

chr11: 68658383–68658836

MRPL21a

3

4.99 × 10–7

 FEV1

 

chr4: 113437801–113438462

NEUROG2, RP11-402J6.1

2

6.18 × 10–158

 

chr1: 7842369–7842406

PER3-003

2

1.33 × 10–142

 

chr8: 144416404–144416485

TOP1MT

2

1.13 × 10–115

 FEV1/FVC

 

chr16: 56715756–56716182

MT1X, RP11-343H19.2

2

1.73 × 10–101

 

chr17: 79905219–79905255

MYADML2

2

1.69 × 10–123

 

chr7: 73256414–73256416

WBSCR27

2

1.91 × 10–17

 

chr20: 3051954–3052221

OXT

2

1.43 × 10–5

  1. DMRcate annotates to UCSC RefGene from the Illumina annotation file
  2. aGenes were not found in Illumina annotation file and were identified using online tool SNIPPER
  3. bCpGs names are provided in Additional file 1: Table S2
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us