Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

Clinical Epigenetics

Table 3 Association of DNA-M at IOW-ALSPAC consistent CpGs with gene expression

CpGs name	Gene name	Chr. no	Location^a	DNA-M at age 10 years with gene expression at age 26 years
CpGs name	Gene name	Chr. no	Location^a	Coeff	P value
Males
cg23131974	ADARB2	10	Body	0.004	0.902
cg24352757	ARHGEF10	8	Body	− 0.095	0.115
cg19957503	ATP11A	13	Body	0.017	0.729
cg27378180	CSPG4	15	Promoter	− 0.002	0.982
cg21049825	DRAM1	12	Intergenic	− 0.071	0.329
cg02304879	FIG4	6	Promoter	− 0.341	0.456
cg02641801	KIF3C	2	Intergenic	− 0.018	0.881
cg04901044	LAMC3	9	Body	− 0.037	0.571
cg16709691	*LMF1*	16	Body	− 0.231	0.022
cg06319475	OPLAH	8	Intergenic	0.002	0.980
cg18499321	RIMBP2	12	Body	− 0.070	0.186
cg14669749	SKI	1	Intergenic	0.009	0.909
cg12655437	*SMAD2*	18	Intergenic	0.199	0.024
cg10605442	YTHDF1	20	Promoter	− 0.004	0.976
cg22904752	ZNF594	17	5′UTR	0.022	0.648
Females
cg24479027	ABR	17	Promoter	-0.048	0.925
cg16049690	*BTNL9*	5	Body	− 0.102	0.034
cg04843085	C11orf45	11	Promoter, 5′UTR	0.004	0.906
cg05299847	CBS	21	Body	− 0.030	0.536
cg18876084	CD2AP	6	Intergenic	− 0.024	0.665
cg25729401	CYTH1	17	Intergenic	− 0.265	0.165
cg07562175	*FBRSL1*	12	Intergenic	0.304	0.045
cg00081919	HAAO	2	Intergenic	− 0.087	0.186
cg13168117	*KLHL30*	2	5′UTR	0.148	0.0043
cg19723734	MAD1L1	7	5′UTR	0.234	0.085
cg06942010	NCOR2	12	Body	0.062	0.465
cg05597624	RNF220	1	5′UTR	− 0.096	0.701
cg12799537	SARNP	12	Body	0.058	0.462
cg23987789	*VAMP3*	1	Intergenic	0.846	0.0285
cg04843085	KCNJ5	11	Promoter, 5′UTR	− 0.100	0.735

The CpGs which showed a significant association with gene expression at 0.05 level were in bold font
^aGenes located at intergenic location were not found in Illumina annotation file and were identified using online tool SNIPPER
Chr. no chromosome number, coeff. coefficient

ISSN: 1868-7083