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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood

Fig. 2

Distinct lung function trajectories from childhood-to-adulthood following comparable patterns in the IOW and ALSPAC cohorts. Note: Among the subjects assigned to each trajectory with a probability > 0.5, most assignments were with a probability ≥ 0.7, much higher than 0.5. In the following, we provide, for each sex and lung function parameter, the percentages of assignments with an assignment probability ≥ 0.7: (1) Among the male participants who were assigned to persistently low lung function trajectories with a probability > 0.5, 173 of 199 (86.9%) for FVC; 178 of 204 (87.3%) for FEV1, and 79 of 96 (82.3%) for FEV1/FVC had a probability ≥ 0.7 of belonging to their trajectory class. (2)The males assigned to high lung function trajectories with a probability > 0.5, 165 of 178, (92.7%) for FVC, 156 of 173 (90.2%) for FEV1, and 267 of 281 (95.0%) for FEV1/FVC had a probability ≥ 0.7 of belonging to the high lung function trajectory group. (3) Among the female participants assigned to each trajectory with a probability > 0.5, 190 of 215 (88.4%) for FVC, 188 of 205 (91.7%) for FEV1, and 78 of 95 (82.1%) for FEV1/FVC in persistently low lung function trajectory group had a probability ≥ 0.7 of belonging to their trajectory class. (4) The females assigned to persistently high lung function trajectories with a probability > 0.5, 195 of 217, (89.9%) for FVC, 191 of 227 (84.1%) for FEV1, and 311 of 337 (92.3%) for FEV1/FVC had a probability ≥ 0.7 of belonging to the normal lung function trajectory group

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