Table 4 Selected significant compounds identified by metabolic profiling of cell lines from the PHMDS (n = 11) and PHMDS Small Del/Mut (n = 9) cohort
Compound (PM plate) | Difference with controls | p value |
|---|---|---|
PHMDS Small Del/Mut | ||
 α-d-Glucose (PM-Trp) | Lower | 0.001 |
PHMDS | ||
 d-Fructose-6-Phosphate (PM-M1) | Lower | 7.26E-05 |
 d-Glucose-1-Phosphate (PM-M1) | Lower | 5.38E-04 |
 d-Glucosaminic acid (PM-M1) | Lower | 2.45E−03 |
 d-Galactose (PM-M1) | Lower | 2.03E−03 |
 β-Hydroxy-butyric acid (PM-M1) | Lower | 3.53E−03 |
 γ-Amino-butyric acid (PM-M1) | Lower | 7.51E−03 |
 α-d-Glucose (PM-M1) | Lower | 0.014 |
 Propionic acid (PM-M1) | Higher | 0.014 |
 d-Glucose-6-Phosphate (PM-M1) | Lower | 0.017 |
 d-Mannose (PM-M1) | Lower | 0.017 |
 N-acetyl-neuraminic acid (PM-M1) | Lower | 0.019 |
 α-Keto-butyric acid (PM-M1) | Lower | 0.019 |
 Pyruvic acid (PM-M1) | Lower | 0.026 |
 Ala-Leu (PM-M2) | Lower | 0.001 |
 Ala-Trp (PM-M2) | Lower | 0.002 |
 Arg-Phe (PM-M2) | Lower | 0.002 |
 His-Tyr (PM-M3) | Lower | 0.007 |
 His-Trp (PM-M3) | Lower | 0.007 |
 His-Val (PM-M3) | Lower | 0.014 |
 l-Tryptophan (PM-Trp) | Lower | 9.37E−03 |
 Trp-Gly (PM-Trp) | Lower | 2.61E−03 |
 Trp-Lys (PM-Trp) | Lower | 6.34E−03 |
 Triiodothyronine (PM-M6, well E3) | Lower | 2.33E−05 |
 Epinephrine (PM-M6, well C3) | Lower | 9.92E−05 |
 Progesterone (PM-M6, well G1) | Lower | 1.51E−04 |
 Resistin (PM-M7, well B5) | Lower | 0.0002 |
 hGH (Somatotropin) (PM-M7, well E3) | Lower | 0.0002 |
 FGF-1 (PM-M7, well F1) | Lower | 0.0002 |
 IL-1β (PM-M7, well G1) | Lower | 0.0002 |