Table 1 Clinical characterisation of subjects in the MCC-Seq study cohort

Age (years)

29.38 ± 0.91 (48)

53.15 ± 0.98 (46)

2.04E−31

Sperm concentrations (× 10⁶/ml)

118.57 ± 15.99 (48)

143.6 ± 18.31 (46)

0.306

Motility (rapid & slow %)

48.96 ± 3.26 (48)

38.77 ± 3.26 (46)

0.029

BMI (kg/m²)

26.45 ± 0.99 (48)

28.94 ± 0.85 (46)

0.059

FSH (IUs/L)

4.09 ± 0.29 (48)

6.25 ± 0.4 (45)

3.66E−05

LH (IUs/L)

3.75 ± 0.17 (48)

4.34 ± 0.32 (45)

0.108

TSH (mIU/L)

2.05 ± 0.34 (47)

1.84 ± 0.21 (42)

0.591

E2RP (qmol/L)

130.97 ± 8.06 (34)

138.24 ± 8.42 (34)

0.535

Testosterone (T, nmol/L)

11.9 ± 0.6 (48)

9.29 ± 0.52 (45)

0.001

Bioavailable T (nmol/L)

6.33 ± 0.27 (48)

5.01 ± 0.61 (43)

0.051

Total cholesterol (mmol/L)

5.21 ± 0.79 (48)

5.06 ± 0.44 (45)

0.863

Triglycerides (mmol/L)

1.83 ± 0.37 (48)

2.89 ± 0.74 (45)

0.202

HDL (mmpl)/L

2.58 ± 1.35 (48)

1.87 ± 0.51 (44)

0.624

LDL (mmol/L)

3.05 ± 0.51 (47)

5.68 ± 2.28 (39)

0.265

Cholesterol/HDL risk ratio

3.9 ± 0.2 (47)

4.06 ± 0.17 (43)

0.544

Smoking

N (%)

N (%)

0.933

 Never

29 (61.7%)

28 (61%)

(χ² = 0.138)

 Past

13 (27.7%)

12 (26%)

 Current

5 (10.6%)

6 (13%)

 NA

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