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Fig. 4 | Clinical Epigenetics

Fig. 4

From: High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations

Fig. 4

Distribution of age-associated hypo- and hypermethylated CpGs in relation to gene region and in chromosome. a Age-associated hypomethylation is proximal to genes, whereas b hypermethylation occupies gene distal regions. We used GREAT (PMID 20436461) analyses to annotate each CpG to its closeset transcription start site (TSS). c A subset of age-associated CpGs are clustered in differentially methylated regions (DMRs) showing higher significances than sporadic age-associated CpGs. d Local density of sperm age-associated hypermethylation (red dots) shows two outlier regions in the genome reaching > 10% density in chr4 and chr16. Density of hypomethylation (green dots) is relatively evenly distributed across the genome. Overall, sex chromosomes are relatively depleted of age-associated CpGs

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