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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA methylation patterns of β-globin cluster in β-thalassemia patients

Fig. 1

Methylation patterns of β-globin cluster in PB tissues. a Schematic of β-globin cluster. The dashed box showed the target regions in DNA methylation examination. b Methylation differences in β0-thalasssmia patients from normal controls (CON) were shown with *p < 0.05, **p < 0.01, ***p < 0.001 in ANCOVA analysis without (under indicated sites) or with (above indicated sites) age covariate. c Methylation level relative to CON (the horizontal dashed line) in TFL (black) or TFH (gray) patients are represented by scatter plot for each CpG site with standard error indicated by bars. *p < 0.05, **p < 0.01, ***p < 0.001 indicated the significant difference in the TFH and/or TFL patients from CON. d, e Methylation pattern between the TFH and TFL patients with age < 5 years (d) and age within 5–15 years (e). #p < 0.05, ##p < 0.01, ###p < 0.001 indicated significant difference from t test between the TFH and THL group in panels of c to e. Five CpG sites (2631 for site 1, 2753 for 2, 2786 for 3, 2868 for HS4-1 and 2928 for HS4-2 relative to the first nucleotide of LCR (chr11:5275850, hg38)) around HS4, five CpG sites (5808 for 1, 5860 for 2, 5943 for 3, 6093 for 4 and 6164 for HS3-1 relative to the first nucleotide of LCR) around HS3, six CpG sites (− 162, − 53, − 50, + 6, + 17 and + 50 relative to the transcriptional start site of γ-globin gene) in the γ-promoter and five CpG sites (− 415, − 307, − 266, − 126 and + 83 relative to the transcriptional start site of β-globin gene) in the β-promoter are shown under each column in panel e  

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