Reproductive technologies, female infertility, and the risk of imprinting-related disorders

Clinical Epigenetics

Table 3 Risk of NDM after ART and according to the type of female infertility in multivariate analysis

	Total children	Children with NDM		Adjusted OR^a	95% CI		p
	N	N	%	Adjusted OR^a	95% CI		p
Mode of conception
NC	3,417,089	1438	0.04	1
Fresh-ET	45,303	38	0.08	1.58	1.13	2.21	0.008
FET	18,885	10	0.05	1.04	0.56	1.96	0.89
IUI	20,218	11	0.05	1.10	0.61	2.00	0.76
Female infertility
Endometriosis	37,398	28	0.07	1.47	1.00	2.16	0.05
PCOS	6977	6	0.09	1.39	0.62	3.13	0.42
POI	1411	2	0.14	1.93	0.47	7.86	0.36

CI confidence interval, Fresh-ET fresh embryo transfer, FET frozen embryo transfer, IUI intrauterine insemination, NC natural conception, OR odds ratio, PCOS polycystic ovary syndrome, POI primary ovarian insufficiency
^aAnalyses were adjusted for maternal parameters: age, primiparity, smoking, obesity, history of high blood pressure, or diabetes

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