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Table 2 Comparison of observed to expected cases for each clinically diagnosed imprinting-related disease according to the type of reproductive technology using univariate analyses (Poisson regression model)

From: Reproductive technologies, female infertility, and the risk of imprinting-related disorders

ICD-10 codes

Imprinting-related diseasesa

Fresh-ET

FET

IUI

Observed cases

Expectedb cases

p

Observed cases

Expected cases

p

Observed cases

Expected cases

p

Q93.5

AS

8

10

0.62

4

4

0.99

4

4

0.90

Q87.3

BWS

8

5

0.18

0

  

2

2

0.88

P70.2

NDM

38

19

< 0.001

10

8

0.50

11

9

0.42

C74.9

Neuroblastoma

2

3

0.57

1

1

0.82

0

  

E20.1

Pseudohypoparathyroidism

0

  

0

  

1

0

0.01

C69.2

Retinoblastoma

3

3

0.86

1

1

0.90

1

1

0.85

Q87.1

SRS/PWS

18

14

0.33

10

6

0.10

4

6

0.35

Q99.8

upd(14)

24

17

0.07

8

7

0.68

10

7

0.34

  1. AS Angelman syndrome, BWS Beckwith–Wiedemann syndrome, Fresh-ET fresh embryo transfer, FET frozen embryo transfer, IUI intrauterine insemination, NDM neonatal diabetes mellitus, PWS Prader–Willi syndrome, SRS Silver–Russell syndrome, Upd uniparental disomy
  2. aDiseases based on clinical features and associated to the corresponding ICD-10 code. Some children could have more than one disease diagnosed
  3. bExpected cases from NC data