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Table 3 Model summary for the allelic dosage effects of rs708727 on the β values at one of the representative CpG probes (cg14159672)

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx Effects Model statistics
variant Estimate SE t value Pr( >|t|) Signif. codes
Control (Intercept) 0.1745 0.1522 1.15 0.254   Residual SD 0.1444
rs708727 0.2662 0.0218 12.23  < 2E−16 *** Multiple r2 0.6267
rs960603 −0.0120 0.0229 −0.52 0.602   Adjusted r2 0.6172
Age 0.0031 0.0019 1.66 0.100   F-statistic 65.9 (4/157 DF)
Sex −0.0165 0.0230 −0.72 0.476   p value  < 2.2E−16
MCI (Intercept) 0.3613 0.1437 2.51 0.013 * Residual SD 0.1532
rs708727 0.2544 0.0228 11.17  < 2E−16 *** Multiple r2 0.5468
rs960603 −0.0125 0.0226 −0.55 0.580   Adjusted r2 0.536
Age 0.0001 0.0019 0.03 0.973   F-statistic 50.97 (4/169 DF)
Sex 0.0030 0.0239 0.13 0.901   p value  < 2.2E−16
AD (Intercept) −0.0555 0.2317 −0.24 0.811   Residual SD 0.173
rs708727 0.2654 0.0455 5.84 1.02E−07 *** Multiple r2 0.5096
rs960603 0.0016 0.0394 0.04 0.968   Adjusted r2 0.4857
Age 0.0036 0.0029 1.27 0.208   F-statistic 21.31 (4/82 DF)
Sex 0.0874 0.0400 2.19 0.032 * p value 4.49E−12
All stable (Intercept) 0.1951 0.0941 2.07 0.039 * Residual SD 0.155
rs708727 0.2643 0.0150 17.58  < 2e−16 *** Multiple r2 0.5638
rs960603 −0.0090 0.0150 −0.60 0.549   Adjusted r2 0.5597
Age 0.0020 0.0012 1.69 0.093   F-statistic 135.1 (4/418 DF)
Sex 0.0143 0.0152 0.94 0.348   p value  < 2.2E−16
  1. Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1
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Clinical Epigenetics

ISSN: 1868-7083

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