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Table 3 Model summary for the allelic dosage effects of rs708727 on the β values at one of the representative CpG probes (cg14159672)

From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression

dx

Effects

Model statistics

variant

Estimate

SE

t value

Pr( >|t|)

Signif. codes

Control

(Intercept)

0.1745

0.1522

1.15

0.254

 

Residual SD

0.1444

rs708727

0.2662

0.0218

12.23

 < 2E−16

***

Multiple r2

0.6267

rs960603

−0.0120

0.0229

−0.52

0.602

 

Adjusted r2

0.6172

Age

0.0031

0.0019

1.66

0.100

 

F-statistic

65.9 (4/157 DF)

Sex

−0.0165

0.0230

−0.72

0.476

 

p value

 < 2.2E−16

MCI

(Intercept)

0.3613

0.1437

2.51

0.013

*

Residual SD

0.1532

rs708727

0.2544

0.0228

11.17

 < 2E−16

***

Multiple r2

0.5468

rs960603

−0.0125

0.0226

−0.55

0.580

 

Adjusted r2

0.536

Age

0.0001

0.0019

0.03

0.973

 

F-statistic

50.97 (4/169 DF)

Sex

0.0030

0.0239

0.13

0.901

 

p value

 < 2.2E−16

AD

(Intercept)

−0.0555

0.2317

−0.24

0.811

 

Residual SD

0.173

rs708727

0.2654

0.0455

5.84

1.02E−07

***

Multiple r2

0.5096

rs960603

0.0016

0.0394

0.04

0.968

 

Adjusted r2

0.4857

Age

0.0036

0.0029

1.27

0.208

 

F-statistic

21.31 (4/82 DF)

Sex

0.0874

0.0400

2.19

0.032

*

p value

4.49E−12

All stable

(Intercept)

0.1951

0.0941

2.07

0.039

*

Residual SD

0.155

rs708727

0.2643

0.0150

17.58

 < 2e−16

***

Multiple r2

0.5638

rs960603

−0.0090

0.0150

−0.60

0.549

 

Adjusted r2

0.5597

Age

0.0020

0.0012

1.69

0.093

 

F-statistic

135.1 (4/418 DF)

Sex

0.0143

0.0152

0.94

0.348

 

p value

 < 2.2E−16

  1. Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘’ 1
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Clinical Epigenetics

ISSN: 1868-7083

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