Fig. 4From: Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progressionMethylation change as disease/age progresses modeled by β values regressed with age at one of the representative CpG probes (cg14893161). Scatter plot is colored by the allelic doses of rs708727 where red = 0 (GG), green = 1 (GA), and blue = 2 (AA) in panels a–c. An overall linear fit line is also shown. Panel a depicts control group, b depicts MCI group, and c depicts AD group. Panel d depicts all the conversion cases where a U-shape is fit and a break point is markedBack to article page