Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

Good, Misty; Chu, Tianjiao; Shaw, Patricia; McClain, Lora; Chamberlain, Austin; Castro, Carlos; Rimer, Jamie M.; Mihi, Belgacem; Gong, Qingqing; Nolan, Lila S.; Cooksey, Krista; Linneman, Laura; Agrawal, Pranjal; Finegold, David N.; Peters, David

doi:10.1186/s13148-020-00983-6

Table 4 Top 30 differentially methylated single CpG sites (DMSs) between NEC and non-NEC ileum

From: Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

chr	Start	End	p value	qvalue	meth.diff	feature.name	name2	dist.to.feature	feature.strand	Intron	mydiff.shores.annot.members
chr2	70827641	70827641	2.11E−23	1.85 E−16	− 95.2406	NM_001258027	CLEC4F	− 7042	−	0	0
chr1	100785163	100785163	4.60 E−21	2.02 E−14	− 52.5346	NM_080682	VCAM1	65,525	+	0	0
chr1	100762620	100762620	2.21 E−17	6.47 E−11	− 59.1667	NM_080682	VCAM1	42,982	+	0	0
chr1	143641173	143641173	6.27 E−17	1.38 E−10	34.04255	NR_104078	RNVU1-17	58,447	–	0	1
chr6	73558525	73558525	9.22 E−17	1.62 E−10	84.61538	NM_001402	EEF1A1	− 37,494	–	0	0
chr11	10964709	10964709	5.72 E−16	8.36 E−10	39.43662	NR_034137	ZBED5-AS1	106,494	+	0	0
chr17	53706550	53706550	4.09 E−15	5.13 E−09	− 71.4286	NM_032559	KIF2B	− 116,328	+	0	0
chr1	100785162	100785162	1.64 E−14	1.80 E−08	− 47.6821	NM_080682	VCAM1	65,524	+	0	0
chr10	53230713	53230713	2.29 E−13	2.23 E−07	36	NM_000242	MBL2	− 459,014	–	0	0
chr8	27077249	27077249	3.38 E−13	2.96 E−07	94.11765	NR_031680	MIR548H4	− 28,287	–	0	0
chr5	36566389	36566389	5.11 E−13	4.08 E−07	31.16883	NM_001289940	SLC1A3	− 39,966	+	0	0
chr5	60868950	60868950	6.00 E−13	4.18 E−07	− 72.093	NM_001104558	ELOVL7	− 24,677	–	0	0
chr7	29003503	29003503	6.20 E−13	4.18 E−07	35.71429	NR_038965	LOC100506497	23,538	+	1	0
chr1	100768520	100768520	1.11 E−12	6.93 E−07	− 55.7692	NM_080682	VCAM1	48,882	+	0	0
chr11	47812794	47812794	1.21 E−12	7.05 E−07	− 86.4865	NM_015231	NUP160	35,751	–	1	0
chr4	147431181	147431181	1.47 E−12	8.06 E−07	− 95.2381	NR_045958	EDNRA	− 49,736	+	0	0
chr1	67009294	67009294	1.81 E−12	9.33 E−07	− 57.8231	NM_015139	SLC35D1	45,104	–	1	0
chr2	45853090	45853090	2.60 E−12	1.27 E−06	94.44444	NM_005400	PRKCE	201,188	+	1	0
chr13	33070399	33070399	3.26 E−12	1.51 E−06	− 70.7317	NM_004795	KL	53,968	+	0	0
chr14	68071519	68071519	4.29 E−12	1.88 E−06	− 80.0909	NM_001321815	RAD51B	247,929	+	1	0
chr13	25087158	25087158	4.95 E−12	2.07 E−06	− 88.8889	NM_030979	PABPC3	− 8980	+	0	0
chr1	100750518	100750518	9.64 E−12	3.68 E−06	− 58.5586	NM_080682	VCAM1	30,880	+	0	0
chr14	22548745	22548745	9.48 E−12	3.68 E−06	73.91304	NR_146543	LINC02332	8318	–	0	0
chr19	7737210	7737210	1.05 E−11	3.84 E−06	− 41.0526	NM_198492	CLEC4G	− 5040	–	0	0
chr2	54973902	54973902	1.29 E−11	4.52 E−06	30.64516	NM_007008	RTN4	36,433	–	1	0
chr5	61059457	61059457	1.71 E−11	5.78 E−06	− 59.7015	NR_109908	SMIM15-AS1	− 102,859	+	1	0
chr1	123215253	123215253	1.80 E−11	5.86 E−06	35.55556	NR_003955	EMBP1	1,696,143	+	0	0
chr5	116099451	116099451	1.91 E−11	5.86 E−06	− 88.3333	NM_001308080	COMMD10	13,991	+	1	0
chr6	33559051	33559051	1.94 E−11	5.86 E−06	− 76.087	NM_001188	BAK1	21,243	–	0	0
chr3	78587902	78587902	2.03 E−11	5.94 E−06	− 85.7143	NM_133631	ROBO1	431,558	–	0	0

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