Skip to main content

Table 4 Top 30 differentially methylated single CpG sites (DMSs) between NEC and non-NEC ileum

From: Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

chr Start End p value qvalue meth.diff feature.name name2 dist.to.feature feature.strand Prom Exon Intron mydiff.CpGi.annot.members mydiff.shores.annot.members mydiff.enhancer.annot.members
chr2 70827641 70827641 2.11E−23 1.85 E−16 − 95.2406 NM_001258027 CLEC4F − 7042 0 0 0 0 0 0
chr1 100785163 100785163 4.60 E−21 2.02 E−14 − 52.5346 NM_080682 VCAM1 65,525 + 0 0 0 0 0 0
chr1 100762620 100762620 2.21 E−17 6.47 E−11 − 59.1667 NM_080682 VCAM1 42,982 + 0 0 0 0 0 0
chr1 143641173 143641173 6.27 E−17 1.38 E−10 34.04255 NR_104078 RNVU1-17 58,447 0 0 0 0 1 0
chr6 73558525 73558525 9.22 E−17 1.62 E−10 84.61538 NM_001402 EEF1A1 − 37,494 0 0 0 0 0 0
chr11 10964709 10964709 5.72 E−16 8.36 E−10 39.43662 NR_034137 ZBED5-AS1 106,494 + 0 0 0 0 0 0
chr17 53706550 53706550 4.09 E−15 5.13 E−09 − 71.4286 NM_032559 KIF2B − 116,328 + 0 0 0 0 0 0
chr1 100785162 100785162 1.64 E−14 1.80 E−08 − 47.6821 NM_080682 VCAM1 65,524 + 0 0 0 0 0 0
chr10 53230713 53230713 2.29 E−13 2.23 E−07 36 NM_000242 MBL2 − 459,014 0 0 0 0 0 0
chr8 27077249 27077249 3.38 E−13 2.96 E−07 94.11765 NR_031680 MIR548H4 − 28,287 0 0 0 0 0 0
chr5 36566389 36566389 5.11 E−13 4.08 E−07 31.16883 NM_001289940 SLC1A3 − 39,966 + 0 0 0 0 0 0
chr5 60868950 60868950 6.00 E−13 4.18 E−07 − 72.093 NM_001104558 ELOVL7 − 24,677 0 0 0 0 0 0
chr7 29003503 29003503 6.20 E−13 4.18 E−07 35.71429 NR_038965 LOC100506497 23,538 + 0 0 1 0 0 0
chr1 100768520 100768520 1.11 E−12 6.93 E−07 − 55.7692 NM_080682 VCAM1 48,882 + 0 0 0 0 0 0
chr11 47812794 47812794 1.21 E−12 7.05 E−07 − 86.4865 NM_015231 NUP160 35,751 0 0 1 0 0 0
chr4 147431181 147431181 1.47 E−12 8.06 E−07 − 95.2381 NR_045958 EDNRA − 49,736 + 0 0 0 0 0 0
chr1 67009294 67009294 1.81 E−12 9.33 E−07 − 57.8231 NM_015139 SLC35D1 45,104 0 0 1 0 0 0
chr2 45853090 45853090 2.60 E−12 1.27 E−06 94.44444 NM_005400 PRKCE 201,188 + 0 0 1 0 0 0
chr13 33070399 33070399 3.26 E−12 1.51 E−06 − 70.7317 NM_004795 KL 53,968 + 0 0 0 0 0 0
chr14 68071519 68071519 4.29 E−12 1.88 E−06 − 80.0909 NM_001321815 RAD51B 247,929 + 0 0 1 0 0 0
chr13 25087158 25087158 4.95 E−12 2.07 E−06 − 88.8889 NM_030979 PABPC3 − 8980 + 0 0 0 0 0 0
chr1 100750518 100750518 9.64 E−12 3.68 E−06 − 58.5586 NM_080682 VCAM1 30,880 + 0 0 0 0 0 0
chr14 22548745 22548745 9.48 E−12 3.68 E−06 73.91304 NR_146543 LINC02332 8318 0 0 0 0 0 0
chr19 7737210 7737210 1.05 E−11 3.84 E−06 − 41.0526 NM_198492 CLEC4G − 5040 0 0 0 0 0 0
chr2 54973902 54973902 1.29 E−11 4.52 E−06 30.64516 NM_007008 RTN4 36,433 0 0 1 0 0 0
chr5 61059457 61059457 1.71 E−11 5.78 E−06 − 59.7015 NR_109908 SMIM15-AS1 − 102,859 + 0 0 1 0 0 0
chr1 123215253 123215253 1.80 E−11 5.86 E−06 35.55556 NR_003955 EMBP1 1,696,143 + 0 0 0 0 0 0
chr5 116099451 116099451 1.91 E−11 5.86 E−06 − 88.3333 NM_001308080 COMMD10 13,991 + 0 0 1 0 0 0
chr6 33559051 33559051 1.94 E−11 5.86 E−06 − 76.087 NM_001188 BAK1 21,243 0 0 0 0 0 0
chr3 78587902 78587902 2.03 E−11 5.94 E−06 − 85.7143 NM_133631 ROBO1 431,558 0 0 0 0 0 0