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Table 3 Top 30 differentially methylated single CpG sites (DMSs) between NEC and non-NEC colon

From: Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

chr Start End p value q value meth.diff feature.name name2 dist.to.feature feature.strand Prom Exon Intron mydiff.CpGi.annot.members mydiff.shores.annot.members mydiff.enhancer.annot.members
chr17 11019015 11019015 1.20E−21 8.39 E−15 40.29664 NM_001101387 PIRT − 180,915 0 0 0 0 0 0
chr2 86062716 86062716 2.67 E−17 9.34 E−11 32.23282 NM_015425 POLR1A 43,440 0 0 1 0 0 0
chr4 115491856 115491856 5.48 E−16 1.28 E−09 40.79545 NM_022569 NDST4 − 377,981 0 0 0 0 0 0
chr14 52272903 52272903 1.95 E−15 3.41 E−09 72.84615 NM_001281469 PTGDR 5192 + 0 0 1 0 0 0
chr10 21066470 21066470 1.40 E−14 1.32 E−08 35.83795 NM_001177483 C10orf113 80,090 0 0 1 0 0 0
chr3 175224788 175224788 1.33 E−14 1.32 E−08 37.83784 NR_046713 NAALADL2-AS2 46,309 0 0 1 0 0 0
chr5 24263140 24263140 1.51 E−14 1.32 E−08 56.26401 NR_131245 C5orf17 311,794 + 0 0 0 0 0 0
chr4 58967547 58967547 2.02 E−14 1.57 E−08 38.96104 NR_133941 LINC02429 − 16,735 + 0 0 0 0 0 0
chr2 79966760 79966760 3.05 E−14 2.14 E−08 55.40583 NR_107047 MIR8080 − 100,178 0 0 1 0 0 0
chr4 22556420 22556420 3.43 E−14 2.18 E−08 45.32618 NM_145290 ADGRA3 − 40,367 0 0 0 0 0 0
chr5 17911285 17911285 3.99 E−14 2.33 E−08 33.63636 NR_134287 LINC02223 104,013 + 0 0 1 0 0 0
chr2 119409733 119409733 4.60 E−14 2.47 E−08 53.94235 NM_183240 TMEM37 − 22,137 + 0 0 0 0 0 0
chr20 38460167 38460167 9.79 E−14 4.89 E−08 42.20401 NR_002986 SNORA60 10,800 + 0 0 0 0 0 0
chr3 101804213 101804213 1.31 E−13 5.91 E−08 51.44188 NM_001005474 NFKBIZ − 23,777 + 0 0 1 0 0 0
chr7 67694175 67694175 1.35 E−13 5.91 E−08 64.74501 NR_120514 LOC102723427 − 326,078 + 0 0 0 0 0 0
chr6 121426895 121426895 1.44 E−13 5.94 E−08 63.50051 NM_000165 GJA1 − 8682 + 0 0 0 0 0 0
chr12 101416276 101416276 1.81 E−13 7.02 E−08 42.5265 NM_001301068 ARL1 − 8457 0 0 0 0 0 0
chr6 78594584 78594584 2.13 E−13 7.85 E−08 50.29663 NM_001010844 IRAK1BP1 − 272,960 + 0 0 0 0 0 0
chr11 12359400 12359400 2.47 E−13 8.05 E−08 38.54167 NM_018222 PARVA − 18,171 + 0 1 0 0 0 0
chr15 63678136 63678136 2.37 E−13 8.05 E−08 55.5917 NR_034080 USP3-AS1 − 77,310 0 1 0 0 0 0
chr6 81046717 81046717 2.53 E−13 8.05 E−08 31.96195 NM_017633 TENT5A 705,995 0 0 0 0 0 0
chr1 167097455 167097455 3.50 E−13 1.02 E−07 66.47619 NM_001080426 DUSP27 3367 + 0 0 1 0 0 0
chr15 81380112 81380112 4.30 E−13 1.20 E−07 44.66705 NM_001080532 TMC3 − 5957 0 0 1 0 0 0
chr2 150152356 150152356 4.63 E−13 1.25 E−07 56.97802 NR_146972 LINC01817 104,652 0 0 0 0 0 0
chr6 167440526 167440526 6.28 E−13 1.47 E−07 47.95134 NR_134591 LOC105378127 32,265 0 0 0 0 0 0
chr16 63305874 63305874 7.40 E−13 1.67 E−07 40.34462 NM_001796 CDH8 − 1E+06 0 0 0 0 0 0
chr10 99591101 99591101 8.02 E−13 1.70 E−07 60.53068 NM_031212 SLC25A28 29,364 0 0 0 0 0 0
chr5 22585518 22585518 7.92 E−13 1.70 E−07 50.73758 NM_001364104 CDH12 267,827 0 0 1 0 0 0
chr8 61783188 61783188 8.72 E−13 1.80 E−07 58.48694 NR_039680 MIR4470 68,402 + 0 0 0 0 0 0
chr19 53612831 53612831 1.15 E−12 2.24 E−07 51.38783 NR_002938 LOC284379 − 9335 0 0 0 0 0 0