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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis

Fig. 4

RNA sequencing of mRNA from ad colon and eh ileum of NEC and control subjects. a, e Heat map of significant (p ≤ 0.05, least squares [LS] mean > 1) differences in RNA expression between NEC and non-NEC a colon or e ileum. b, f Principle component analysis of RNA expression in NEC and non-NEC b colon and f ileum. c, g Volcano plot of c colon or g ileum RNA expression fold change (X-axis) and p value (Y-axis). Highlighted dots represent genes that have a p value of less than 0.05 and a fold change of at least 2. d, h The 20 most significant results from functional pathway analysis of differentially expressed genes in d colon or h ileum

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