|
HDACs
|
SAHA, ITF2357
|
Suppression of P. gingivalis- and cytokine-induced CCL2, CCL5, CXCL10, MMP1, MMP3 and PTGS expression in gingival fibroblasts [53]
|
|
TSA, butyrate
|
Upregulation of hBD2, IL-8 and CCL20 in GECs infected with P. gingivalis or F. nucleatum [35]
|
|
butyrate
|
Suppression of LPS-induced TNF and IL-1β expression and ROS production in PDL cells [56]
|
|
TSA, apicidin
|
Suppression of T. denticola-induced MMP2 activation in PDL cells [29]
|
|
TSA, butyrate
|
Upregulation of osteoblast markers and induction of osteogenic differentiation of PDL cells [56, 57]
|
|
1179.4b
|
Reduction of alveolar bone destruction in experimental periodontitis in mice [69]
|
|
TSA
|
Reduction of inflammation and increased alveolar bone volume in experimental periodontitis in rats [68]
|
|
BET proteins
|
I-BET151, JQ1
|
Suppression of inflammatory mediator production by GECs and gingival fibroblasts [65]
|
|
JQ1
|
Amelioration of inflammation and alveolar bone resorption in experimental periodontitis in mice [70]
|
|
DNMTs
|
AZA
|
Induction of differentiation of gingival fibroblasts into osteoblasts and induction of ectopic bone formation in mice [120]
|
|
Suppression of T. denticola-induced MMP2 activation in PDL cells [29]
|
|
AZA, decitabine
|
Modulation of inflammatory cytokine production by GECs [121]
|
|
RG108
|
Prevention of P. gingivalis-mediated impairment of GEC barrier function [114]
|
