Table 4 Mechanisms and clinical value of ncRNAs in keloid
From: Epigenetic modification mechanisms involved in keloid: current status and prospect
ncRNAs | Expression | Target gene | Mechanism | Clinical value | Ref |
|---|---|---|---|---|---|
miR-152-3p | Upregulation | FOXF1 | MiR-152-3p regulated cell proliferation, invasion and ECM expression through targeting FOXF1 in KFs | A novel and promising molecular target for keloid treatment | [63] |
miRNA-31 | Upregulation | HIF1AN | MiRNA-31 regulated proliferation, apoptosis, and cell cycle of keloid-derived fibroblasts by mediating HIF1AN/VEGF signaling pathway | A promising therapeutic target in keloid scarring | [64] |
miR-181a | Upregulation | PHLPP2 | MiR-181a targeted PHLPP2 to augment AKT signaling and regulate proliferation and apoptosis in human KFs | A therapeutic target for treatment of keloids | [65] |
miR-21 | Upregulation | TGF-β1 | TGF-β1 increased the promoting actions of miR-21 on the proliferation and migration of KFs while attenuating apoptosis | A novel evidence on a theoretical basis for keloid treatment | [66] |
miR-21 | Upregulation | TGF-β1 | TGF-β1 promoted KFs proliferation and transdifferentiation via up-regulation of miR-21 and PTENAKT signaling pathway | A potential theoretical basis for clinical treatment of keloids | [67] |
miR-21-5p | Upregulation | PTEN | MiR-21-5p increased the migration, invasion, sphere-forming abilities of keloid keratinocytes, the phenotype of EMT, and cells stemness | A novel therapeutic targets for keloids | [68] |
miR-21 | Upregulation | FasL | MiR-21 regulated the apoptosis of KFs by caspase-8 and mitochondrial-mediated apoptotic signaling pathway | A therapeutic target for keloids | [69] |
miR-21 | Upregulation | Smad7 | MiR-21 promoted Col1A1 and Col3A1 expression in keloid-derived fibroblast | A potential target for keloid treatment | [70] |
miR-196a | Downregulation | COL1A1 and COL3A1 | MiR-196a downregulation increased the collagens expression in KFs | A new therapeutic target for keloid lesions | [71] |
miR-200b | Downregulation | N/A | MiR-200b inhibited the cell proliferation and promoted apoptosis of fibroblast via TGF-β1/a-SMA signaling | A useful target for hypertrophic scarring management | [72] |
miR-29a | Downregulation | COL3A1 | MiR-29a markedly reduced Type I and type III collagen mRNA and protein levels | A novel marker for keloids | [73] |
miR-205-5p | Downregulation | VEGF | MiR-205-5p overexpression induced the cell apoptosis, and inhibited the cell invasion and migration ability in KFs | A potential therapy for prevention and treatment of keloids | [74] |
miR-141-3p | Downregulation | GAB1 | MiR-141-3p inhibited fibroblast proliferation and migration in keloids | A useful target for keloid management | [75] |
miR-188-5p | Downregulation | N/A | MiR-1224-5p regulated proliferation, apoptosis, and invasion via the TGF-β1/Smad3 signaling pathway in KFs | A possible new therapeutic strategy for keloids | [76] |
miR-203 | Downregulation | EGR1 and FGF2 | MiR-203 overexpression resulted in a significant decrease in proliferation, invasion, and ECM production in KFs | A potential role in preventing and treating keloids | [77] |
miR-152-5p | Downregulation | Smad3 | MiR-152-5p inhibited proliferation and migration and promotes apoptosis via the Erk1/2 and Akt pathways in human KFs | A potential therapeutic target of keloids | [78] |
miR‑637 | Downregulation | Smad3 | MiR-637 inhibited KFs proliferation and metastasis | A promising therapeutic target in keloids | [79] |
miR-188-5p | Downregulation | N/A | MiR-188-5p regulated proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids | A potential prognostic marker and therapeutic target for keloids | [80] |
miR-4417 | Downregulation | CyclinD1 | MiR-4417 suppressed keloid fibrosis growth by inhibiting CyclinD1 | A potential therapeutic target in keloids | [81] |
miR-1-3p and miR-214-5p | Downregulation | TM4SF1 | MiR-1-3p and miR-214-5p inhibited cell proliferation, migration, and induced apoptosis in HKFs | A potential targets in therapies for keloids | [82] |
lncRNA-H19 | Upregulation | miR-29a | LncRNA-H19 affected the viability and apoptosis of KFs through COL1A1 signaling | LncRNA-H19 was expected to allow for development of keloid-targeted treatments | [102] |
lncRNAHOXA11-AS | Upregulation | miR-124-3p | High expression of HOXA11-AS essentially inhibited cell apoptosis and promoted fibroblast-induced angiogenesis via PI3K/Akt signaling pathway | A novel target for keloid therapy | [84] |
lncRNA CAS1 | Upregulation | N/A | LncRNA-CAS1 promoted calcium channel protein and type I collagen expression, and had a positive effect on cell migration in human KFs | A new therapeutic target for keloids | [85] |
lncRNA-ATB | Upregulation | miR-200c | Knockdown of lncRNA-ATB decreased autocrine secretion of TGF-β2 | Potential biomarkers and targets for novel diagnostic and therapeutic approaches for keloids | [86] |
circRNA_0008259 | Downregulation | N/A | Overexpression of circRNA_0008259 inhibited type I and collagen expression | Act as biomarkers of keloid | [47] |
circCOL3A1-859267 | Downregulation | miR-29c | circCOL3A1-859267 regulated type I collagen expression in fibroblasts | NA | [87] |