From: Epigenetic modification mechanisms involved in keloid: current status and prospect
Histone modification classification | Inhibitor | Target | Mechanism | Clinical value | Ref |
---|---|---|---|---|---|
Histone acetylation | N/A | N/A | N/A | N/A | Â |
Histone deacetylation | CUDC-907 | HDACs | CUDC-907 inhibited cell proliferation, migration, invasion, and ECM deposition in KFs and also disrupted the capillaries of keloid explants ex vivo and in vivo | A candidate drug for systemic keloid therapy | [59] |
Histone deacetylation | TSA | HDACs | TSA could also cause abrogation of TGF-β1 induced collagen synthesis and induce apoptosis of proliferating KFs | TSA might increase the sensitivity of keloid to radiotherapy and become primary or adjunctive agents for the management of keloid | [60] |
Histone deacetylation | TSA | HDACs | TSA-induced miR-30a-5p regulated apoptosis and proliferation of keloid fibroblasts via targeting BCL2 | A potential use for TSA as effective therapeutic strategies for keloids | [62] |