From: Epigenetic modification mechanisms involved in keloid: current status and prospect
DNA methylation | Expression | Mechanism | Clinical value | Ref |
---|---|---|---|---|
HOXA9/HOXA10 | Hypermethylation | DNA methylation altered wound healing in keloid fibroblasts | Strategies to treat or prevent keloids | [50] |
CDC2L1 | Hypermethylation | DNA methylation of the CDC2L1 gene promoter resulted in decreased fibroblast apoptosis, thus promoting the development of keloids | The potential therapeutic value in the process of wound healing for preventing keloid development | [14] |
SFRP1 | Hypermethylation | The SFRP1 promoter methylation significantly promoted the signaling activity of Wnt/β-catenin and the mRNA and protein expression of β-catenin and α-SMA in keloid fibroblasts | A therapeutic target for keloid treatment | [52] |
POMC | Hypermethylation | POMC gene promoter methylation would not account for the development of hypopigmentation in keloid | N/A | [53] |