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Table 1 The expression profiles of miRNAs, lncRNAs, and circRNAs in keloid

From: Epigenetic modification mechanisms involved in keloid: current status and prospect

ncRNAs Sample Number (cases/controls) DE ncRNAs (up/down) Up-regulated ncRNAs verified by qRT-PCR Down-regulated ncRNAs verified by qRT-PCR KEGG enrichment analysis Ref
MiRNAs Skin tissue 3/3 40 (27/13) miR-370-3p miR-204-5p Regulation of actin cytoskeleton pathway
Yersinia infection pathway
Proteoglycans in cancer pathway
[37]
Skin tissue 3/3 12 (6/6) N/A miR-194-3p N/A [31]
Skin tissue 3/3 264 (139/125) miR-199a-5p
miR-21-5p
miR-214-5p
miR-424-5p
miR-205-5p MAPK signaling pathway
HIF-1 signaling pathway
Prolactin signaling pathway
[32]
Skin tissue 8/8 293 (168/125) N/A miR-199a-5p N/A [30]
Skin tissue 12/12 32 (23/9) miR-21
miR-4269
miR-382
miR-203
miR-205
miR-200c
Cell cycle pathway
MAPK pathway
P53 pathway
[28]
Skin tissue 5/5 74 (46/28) N/A miR-1224-5p N/A [76]
Fibroblast 3/3 9 (6/3) miR-4328 miR-152
miR-145-5p
miR-320c
miR-30a-5p
TGF-β pathway
MAPK pathway
Apoptosis and cell cycle pathway
[29]
Serum 9/7 37 (17/20) miR-1225-5p
miR195-5p,
miR-513-5p
miR-6801-3p
miR-4254
miR-412-3p
PI3K-Akt signaling pathway
MAPK signaling pathway
Ras signaling pathway
[33]
LncRNAs Skin tissue 3/3 319 (251/68) lnc-CASP9-3 lnc-GLB1L-1 ErbB pathway
Phospholipase D pathway
[37]
Skin tissue 2/2 2227 (1224/1003) N/A N/A Cancer pathway
Metabolic transcriptional misregulation pathway
RAS pathway
[41]
Skin tissue 4/4 30 (16/14) LOC100271722 HNF1A-AS1 Notch pathway
Wnt pathway
Hippo pathway
[42]
Skin tissue 4/4 69 (38/31) CACNA1G-AS1
HOXA11AS
LINC00312
RP11-91I11.1
AP001476.4
RP4-794H19.4
AC004074.3
Wnt pathway [43]
Skin tissue and Fibroblast 5/5 and 3/3 3680 (2238/1442) and 5448 (2526/2922) ENST00000439703
uc003jox.1
N/A Wnt pathway
PI3K-Akt pathway
PPAR signaling pathway
[39]
Skin tissue 3/3 2068 (1290/778) NONHSAT120157
NONHSAT062994 NONHSAT016933
NR 024360.1
FR39263
NONHSAT053431
FR244962
ENST00000601148
TCONS 00022478
XR 244388.1
Focal adhesion pathway
Metabolic pathway
ECM-receptor interaction pathway
[40]
Skin tissue 3/3 2513 (1731/782) ENST00000522743
NR-038439
uc0021fu.1
ENST00000521141 ECM-receptor interaction pathway
Calcium pathway
MRNA surveillance pathway
[38]
Skin tissue 6/6 3469 (2479/990) ENSG00000251085
ENSG0000 0223749
ENSG0000 0258876
ENSG0000 0237548
ENSG0000 0268262 TNF pathway
TGF-β pathway
Jak-STAT pathway
[49]
CircRNAs Fibroblast 3/3 411 (206/205) circRNA-0008259
circRNA-0005480
circRNA-0002198 Focal adhesion pathway
PI3K-Akt pathway
Metabolic pathway
[47]
Skin tissue 3/3 76 (52/24) N/A circRNA-0057452, circRNA-0007482, circRNA-0020792, circRNA-0057342 circRNA-0043688 cAMP pathway
Cell cycle pathway
Cancer pathway
[48]
Skin tissue 2/2 154 (81/73) N/A circRNA-0000994 Focal adhesion pathway
Actin cytoskeleton pathway
PI3K-Akt pathway
[41]
Skin tissue 6/6 11 (10/1) circ17-50190326-50194041
circ17-50189167-50194626
circ17-50189858-50195330
circ17-50189167-50198002
circ11-33286412-33287511
circ2-72718102-72733118
ECM-receptor interaction pathway
Gap junction pathway
Protein digestion and absorption pathway
[49]
  1. DE ncRNAs were verified to be mainly associated with multiple signaling pathways involved in proliferation, migration, apoptosis, and differentiation through high-throughput sequencing and bioinformatics analysis. Meanwhile, qRT-PCR verification is further methods of confirming the identified dysregulated ncRNAs. NA not available, DE differentially expressed, ncRNAs non-coding RNAs, miRNAs microRNAs, lncRNAs long non-coding RNAs, circRNAs circular RNAs; qRT-PCR quantitative reverse transcription-polymerase chain reaction, KEGG Kyoto Encyclopedia of Genes and Genomes