Fig. 2
From: Epigenetic modification mechanisms involved in keloid: current status and prospect
Illustration of the main epigenetic mechanisms (DNA methylation, histone modifications, and ncRNAs) involved in the regulation of keloid progression including aberrant proliferation, myofibroblast activation, apoptosis, cell cycle, migration, and collagen production. DNMT: DNA methyltransferase; TET ten-eleven translocation, 5mC 5-methylated cytosine, 5fC 5-formylcytosine cytosine, 5-hmC 5-hydroxymethylated cytosine, 5caC 5-carboxylcytosine cytosine, TDG thymine DNA glycosylase, me methylation, ac acetylation, pho phosphorylation, ub ubiquitination, sum sumoylation