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Table 2 Significantly different gene sets related to renal and cardiovascular development, function or health

From: Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction

Gene set name Up or down p value FDR Brief description
KEGG_CARDIAC_MUSCLE_CONTRACTION Down 0.0002 0.0052 Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes
GO_KIDNEY_EPITHELIUM_DEVELOPMENT Up 0.0003 0.0080 The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure
GO_RENAL_FILTRATION Up 0.0003 0.0081 Renal system process in which fluid circulating through the body is filtered through a barrier system
GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT Up 0.0007 0.0126 The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure
GO_CARDIAC_SEPTUM_DEVELOPMENT Up 0.0009 0.0145 The progression of a cardiac septum over time, from its initial formation to the mature structure
REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K Down 0.0012 0.0172 Erythropoietin activates phosphoinositide-3-kinase
GO_RENAL_SYSTEM_DEVELOPMENT Up 0.0015 0.0207 The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure
REACTOME_SIGNALING_BY_ERYTHROPOIETIN Down 0.0026 0.0296 Signaling by erythropoietin
GO_KIDNEY_MESENCHYME_DEVELOPMENT Up 0.0042 0.0426 The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Down 0.0067 0.060 Cell surface interactions at the vascular wall
REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Down 0.0079 0.0671 Synthesis of very long-chain fatty acyl-CoAs
GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT Up 0.0088 0.0712 The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state
GO_REGULATION_OF_GLOMERULAR_FILTRATION Up 0.0115 0.0847 Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule
REACTOME_TRIGLYCERIDE_METABOLISM Down 0.0141 0.0947 Triglyceride metabolism
  1. Ordered according to lowest false discovery rate (FDR)