Table 2 Significantly different gene sets related to renal and cardiovascular development, function or health
Gene set name | Up or down | p value | FDR | Brief description |
|---|---|---|---|---|
KEGG_CARDIAC_MUSCLE_CONTRACTION | Down | 0.0002 | 0.0052 | Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes |
GO_KIDNEY_EPITHELIUM_DEVELOPMENT | Up | 0.0003 | 0.0080 | The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure |
GO_RENAL_FILTRATION | Up | 0.0003 | 0.0081 | Renal system process in which fluid circulating through the body is filtered through a barrier system |
GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT | Up | 0.0007 | 0.0126 | The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure |
GO_CARDIAC_SEPTUM_DEVELOPMENT | Up | 0.0009 | 0.0145 | The progression of a cardiac septum over time, from its initial formation to the mature structure |
REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K | Down | 0.0012 | 0.0172 | Erythropoietin activates phosphoinositide-3-kinase |
GO_RENAL_SYSTEM_DEVELOPMENT | Up | 0.0015 | 0.0207 | The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure |
REACTOME_SIGNALING_BY_ERYTHROPOIETIN | Down | 0.0026 | 0.0296 | Signaling by erythropoietin |
GO_KIDNEY_MESENCHYME_DEVELOPMENT | Up | 0.0042 | 0.0426 | The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure |
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Down | 0.0067 | 0.060 | Cell surface interactions at the vascular wall |
REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Down | 0.0079 | 0.0671 | Synthesis of very long-chain fatty acyl-CoAs |
GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT | Up | 0.0088 | 0.0712 | The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state |
GO_REGULATION_OF_GLOMERULAR_FILTRATION | Up | 0.0115 | 0.0847 | Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule |
REACTOME_TRIGLYCERIDE_METABOLISM | Down | 0.0141 | 0.0947 | Triglyceride metabolism |