|
Outcomes
|
Models
|
All stages
|
Stage I and II
|
Stage III
|
Stage IV
|
|---|
|
All-cause mortality
|
Common predictors*
|
0.739 (0.723, 0.754)
|
0.693 (0.667, 0.719)
|
0.653 (0.622, 0.683)
|
0.557 (0.520, 0.594)
|
|
+DNAmMRscore#
|
0.747 (0.732, 0.762)
|
0.709 (0.684, 0.735)
|
0.668 (0.638, 0.698)
|
0.592 (0.554, 0.629)
|
|
+AgeAccelPheno#
|
0.746 (0.731, 0.761)
|
0.708 (0.683, 0.734)
|
0.662 (0.632, 0.692)
|
0.587 (0.552, 0.623)
|
|
+AgeAccelGrim#
|
0.754 (0.740, 0.769)
|
0.725 (0.700, 0.749)
|
0.671 (0.641, 0.700)
|
0.589 (0.551, 0.627)
|
|
CRC-specific mortality
|
Common predictors*
|
0.809 (0.792, 0.825)
|
0.612 (0.559, 0.666)
|
0.608 (0.568, 0.648)
|
0.557 (0.519, 0.595)
|
|
+DNAmMRscore#
|
0.815 (0.798, 0.831)
|
0.633 (0.582, 0.685)
|
0.635 (0.595, 0.675)
|
0.589 (0.551, 0.627)
|
|
+AgeAccelPheno#
|
0.813 (0.797, 0.829)
|
0.636 (0.584, 0.688)
|
0.621 (0.582, 0.660)
|
0.586 (0.549, 0.623)
|
|
+AgeAccelGrim#
|
0.814 (0.798, 0.830)
|
0.646 (0.596, 0.697)
|
0.626 (0.586, 0.665)
|
0.584 (0.545, 0.623)
|
- AgeAccel, age acceleration; CI, confidence interval; MRscore, DNA methylation mortality risk score
- *Common predictors include age, sex, tumor stage for overall C-statistics, and age and sex for stage-specific C-statistics
- #Models include common predictors and the corresponding DNA methylation aging algorithm
