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Table 5 Harrell’s C-statistics (95% CI) for all-cause mortality and CRC-specific mortality prediction

From: Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Outcomes Models All stages Stage I and II Stage III Stage IV
All-cause mortality Common predictors* 0.739 (0.723, 0.754) 0.693 (0.667, 0.719) 0.653 (0.622, 0.683) 0.557 (0.520, 0.594)
+DNAmMRscore# 0.747 (0.732, 0.762) 0.709 (0.684, 0.735) 0.668 (0.638, 0.698) 0.592 (0.554, 0.629)
+AgeAccelPheno# 0.746 (0.731, 0.761) 0.708 (0.683, 0.734) 0.662 (0.632, 0.692) 0.587 (0.552, 0.623)
+AgeAccelGrim# 0.754 (0.740, 0.769) 0.725 (0.700, 0.749) 0.671 (0.641, 0.700) 0.589 (0.551, 0.627)
CRC-specific mortality Common predictors* 0.809 (0.792, 0.825) 0.612 (0.559, 0.666) 0.608 (0.568, 0.648) 0.557 (0.519, 0.595)
+DNAmMRscore# 0.815 (0.798, 0.831) 0.633 (0.582, 0.685) 0.635 (0.595, 0.675) 0.589 (0.551, 0.627)
+AgeAccelPheno# 0.813 (0.797, 0.829) 0.636 (0.584, 0.688) 0.621 (0.582, 0.660) 0.586 (0.549, 0.623)
+AgeAccelGrim# 0.814 (0.798, 0.830) 0.646 (0.596, 0.697) 0.626 (0.586, 0.665) 0.584 (0.545, 0.623)
  1. AgeAccel, age acceleration; CI, confidence interval; MRscore, DNA methylation mortality risk score
  2. *Common predictors include age, sex, tumor stage for overall C-statistics, and age and sex for stage-specific C-statistics
  3. #Models include common predictors and the corresponding DNA methylation aging algorithm