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Table 4 Associations of DNA methylation aging markers with CRC-specific mortality

From: Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Markers Categories All stages Stage I and II Stage III Stage IV P for interaction
ndeath/ncases HR (95% CI)* ndeath/ncases HR (95% CI)# ndeath/ncases HR (95% CI)# ndeath/ncases HR (95% CI)#
AgeAccelHorvath Tertile 1 203/732 1.00 (Ref.) 34/362 1.00 (Ref.) 75/257 1.00 (Ref.) 93/105 1.00 (ref.)
Tertile 2 184/731 1.03 (0.83, 1.28) 32/401 0.88 (0.54, 1.45) 69/234 1.02 (0.73, 1.42) 82/91 1.11 (0.80, 1.52)
Tertile 3 209/728 1.17 (0.94, 1.46) 49/390 1.67 (1.06, 2.65) 67/230 1.17 (0.83, 1.66) 92/109 0.95 (0.68, 1.31)
Per SD increase 596/2191 1.04 (0.95, 1.13) 115/1153 1.17 (0.97, 1.41) 211/721 1.07 (0.93, 1.24) 267/305 0.94 (0.81, 1.08) 0.256
AgeAccelHannum Tertile 1 173/732 1.00 (Ref.) 28/384 1.00 (Ref.) 77/266 1.00 (Ref.) 68/78 1.00 (ref.)
Tertile 2 204/731 0.93 (0.73, 1.17) 45/386 1.46 (0.89, 2.40) 61/234 0.82 (0.57, 1.18) 98/110 0.88 (0.60, 1.29)
Tertile 3 219/728 1.06 (0.83, 1.36) 42/383 1.24 (0.72, 2.12) 73/221 1.13 (0.78, 1.65) 101/117 0.90 (0.60, 1.35)
Per SD increase 596/2191 1.07 (0.97, 1.19) 115/1153 1.05 (0.84, 1.31) 211/721 1.10 (0.94, 1.29) 267/305 1.02 (0.87, 1.20) 0.258
DNAmMRscore Tertile 1 166/733 1.00 (Ref.) 31/409 1.00 (Ref.) 63/241 1.00 (Ref.) 72/83 1.00 (ref.)  
Tertile 2 176/729 0.90 (0.68, 1.17) 38/395 1.07 (0.61, 1.86) 53/229 0.81 (0.53, 1.25) 84/101 0.82 (0.56, 1.21)  
Tertile 3 254/729 1.54 (1.11, 2.15) 46/349 1.38 (0.71, 2.66) 95/251 1.61 (1.00, 2.57) 111/121 1.21 (0.77, 1.88)
Per SD increase 596/2191 1.30 (1.11, 1.53) 115/1153 1.34 (0.99, 1.81) 211/721 1.36 (1.10, 1.67) 267/305 1.06 (0.86, 1.29) 0.041
AgeAccelPheno Tertile 1 168/732 1.00 (Ref.) 30/389 1.00 (Ref.) 72/262 1.00 (Ref.) 65/78 1.00 (ref.)
Tertile 2 196/731 1.20 (0.96, 1.51) 40/394 1.08 (0.66, 1.78) 63/231 1.01 (0.70, 1.45) 93/101 1.51 (1.06, 2.14)
Tertile 3 232/728 1.25 (0.98, 1.59) 45/370 1.38 (0.84, 2.29) 76/228 1.26 (0.89, 1.79) 109/126 1.26 (0.88, 1.81)
Per SD increase 596/2191 1.15 (1.04, 1.27) 115/1153 1.18 (0.97, 1.42) 211/721 1.22 (1.06, 1.42) 267/305 1.08 (0.92, 1.25) 0.281
AgeAccelGrim Tertile 1 175/732 1.00 (Ref.) 32/404 1.00 (Ref.) 80/257 1.00 (Ref.) 63/70 1.00 (ref.)
Tertile 2 188/731 0.92 (0.73, 1.17) 38/379 1.14 (0.68, 1.93) 60/245 0.79 (0.54, 1.15) 90/103 0.92 (0.64, 1.34)
Tertile 3 233/728 1.28 (0.84, 1.93) 45/370 1.53 (0.85, 2.73) 71/219 1.19 (0.80, 1.77) 114/132 0.94 (0.65, 1.37)
Per SD increase 596/2191 1.26 (1.09, 1.45) 115/1153 1.24 (0.99, 1.56) 211/721 1.10 (0.92, 1.31) 267/305 1.18 (1.00, 1.40) 0.036
  1. AgeAccel, age acceleration; CI, confidence interval; DNAm, DNA methylation; HR, hazard ratio; MRscore, mortality risk score
  2. Numbers printed in bold: statistically significantly different from 1 (P < 0.05)
  3. *Overall HR was adjusted for age, sex, batch effects, tumor stage and leukocyte composition (Houseman’s algorithm)
  4. #Stage-specific HR was adjusted for age, sex, batch effects and leukocyte composition (Houseman’s algorithm)