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Table 3 Associations of DNA methylation aging markers with all-cause mortality

From: Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Markers Categories All stages Stage I and II Stage III Stage IV P for interaction
ndeath/ncases HR (95% CI)* ndeath/ncases HR (95% CI)# ndeath/ncases HR (95% CI)# ndeath/ncases HR (95% CI)#
AgeAccelHorvath Tertile 1 361/736 1.00 (Ref.) 135/364 1.00 (Ref.) 124/260 1.00 (Ref.) 100/107 1.00 (Ref.)
Tertile 2 339/736 1.01 (0.86, 1.18) 138/402 0.97 (0.76, 1.24) 109/236 0.95 (0.73, 1.25) 87/92 1.14 (0.83, 1.55)
Tertile 3 379/734 1.17 (0.99, 1.38) 163/393 1.32 (1.04, 1.38) 117/230 1.18 (0.90, 1.55) 98/110 0.98 (0.71, 1.34)
Per SD increase 1079/2206 1.06 (0.99, 1.13) 436/1159 1.10 (0.99, 1.21) 350/726 1.10 (0.99, 1.23) 285/309 0.96 (0.84, 1.10) 0.139
AgeAccelHannum Tertile 1 327/736 1.00 (Ref.) 128/386 1.00 (Ref.) 124/268 1.00 (Ref.) 74/80 1.00 (Ref.)
Tertile 2 340/736 0.93 (0.78, 1.09) 126/387 0.89 (0.69, 1.15) 109/235 0.93 (0.70, 1.24) 103/111 0.86 (0.60, 1.24)
Tertile 3 412/734 1.12 (0.94, 1.33) 182/386 1.18 (0.91, 1.53) 117/223 1.14 (0.84, 1.55) 108/118 0.91 (0.62, 1.34)
Per SD increase 1079/2206 1.06 (0.98, 1.14) 436/1159 1.05 (0.93, 1.17) 350/726 1.11 (0.98, 1.26) 285/309 1.00 (0.86, 1.17) 0.475
DNAmMRscore Tertile 1 275/736 1.00 (Ref.) 102/410 1.00 (Ref.) 97/242 1.00 (Ref.) 76/84 1.00 (Ref.)  
Tertile 2 346/736 1.07 (0.89, 1.30) 147/399 1.27 (0.94, 1.70) 104/231 0.97 (0.71, 1.34) 92/102 0.89 (0.61, 1.29)  
Tertile 3 458/734 1.66 (1.32, 2.09) 187/350 2.01 (1.42, 2.85) 149/253 1.64 (1.13, 2.38) 117/123 1.33 (0.87, 2.04)
Per SD increase 1079/2206 1.34 (1.20, 1.49) 436/1159 1.50 (1.28, 1.76) 350/726 1.39 (1.18, 1.64) 285/309 1.09 (0.90, 1.33) 0.616
AgeAccelPheno Tertile 1 318/736 1.00 (Ref.) 122/390 1.00 (Ref.) 123/263 1.00 (Ref.) 71/80 1.00 (Ref.)
Tertile 2 323/736 1.02 (0.86, 1.20) 126/395 0.89 (0.68, 1.15) 99/234 0.92 (0.69, 1.22) 96/102 1.43 (1.02, 2.01)
Tertile 3 438/734 1.35 (1.14, 1.59) 188/374 1.50 (1.17, 1.92) 128/229 1.28 (0.98, 1.69) 118/127 1.31 (0.93, 1.86)
Per SD increase 1079/2206 1.18 (1.10, 1.27) 436/1159 1.22 (1.11, 1.35) 350/726 1.20 (1.07, 1.35) 285/309 1.12 (0.97, 1.30) 0.459
AgeAccelGrim Tertile 1 286/736 1.00 (Ref.) 98/405 1.00 (Ref.) 119/258 1.00 (Ref.) 68/72 1.00 (Ref.)
Tertile 2 347/736 1.13 (0.94, 1.34) 144/381 1.34 (1.00, 1.78) 106/246 0.98 (0.73, 1.32) 95/104 0.95 (0.66, 1.37)
Tertile 3 446/734 1.65 (1.37, 2.00) 194/373 2.30 (1.69, 3.13) 125/222 1.63 (1.19, 2.22) 122/133 1.01 (0.71, 1.45)
Per SD increase 1079/2206 1.35 (1.24, 1.47) 436/1159 1.48 (1.31, 1.66) 350/726 1.24 (1.08, 1.43) 285/309 1.23 (1.05, 1.44) 0.082
  1. AgeAccel, age acceleration; CI, confidence interval; DNAm, DNA methylation; HR, hazard ratio; MRscore, mortality risk score
  2. Numbers printed in bold: statistically significantly different from 1 (P < 0.05)
  3. *Overall HR was adjusted for age, sex, batch effects, tumor stage and leukocyte composition (Houseman’s algorithm)
  4. #Stage-specific HR was adjusted for age, sex, batch effects and leukocyte composition (Houseman’s algorithm)