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Table 2 Clinical characteristics at baseline in the DACHS study

From: Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study

Baseline Characteristics Values
Sex, n (%)  
 Women 910 (41.2)
 Men 1296 (58.8)
Age at diagnosis, n (%)  
 33 ≤–< 55 years 238 (10.8)
 55 ≤–< 65 years 479 (21.7)
 65 ≤–< 75 years 776 (35.2)
 75 ≤–≤ 96 years 713 (32.3)
Tumor stage, n (%)*  
 I 400 (18.2)
 II 760 (34.6)
 III 726 (33.1)
 IV 309 (14.1)
Leukocyte composition, Median (IQR)#  
 CD4 + T cells 0.12 (0.07, 0.17)
 CD8 + T cells 0.03 (0.004, 0.06)
 NK cells 0.07 (0.04, 0.11)
 B cells 0.04 (0.03, 0.06)
 Monocytes 0.08 (0.06, 0.10)
 Granulocytes 0.65 (0.56, 0.74)
Charlson comorbidity index, n (%)  
 0 (no comorbidity) 1282 (58.1)
 1 (mild comorbidity) 479 (21.7)
 2 (moderate comorbidity) 264 (12.0)
 3+ (severe comorbidity) 182 (8.2)
Tumor sub-site, n (%)*  
 Proximal colon 796 (36.1)
 Distal colon 738 (33.5)
 Rectum 670 (30.4)
BMI at diagnosis, n (%)*
 < 25 kg/m2 834 (38.0)
 25 ≤–< 30 kg/m2 932 (42.4)
 ≥ 30 kg/m2 430 (19.6)
Alcohol consumption, n (%)*
 Abstainer 380 (17.3)
 Female: < 20 g/day; Male: < 40 g/day 1559 (70.9)
 Female: ≥ 20 g/day; Male: ≥ 40 g/day 260 (11.8)
Smoking status, n (%)*  
 Never 907 (41.1)
 Former 948 (43.0)
 Current 350 (15.9)
  1. BMI, body mass index; char, characteristics; IQR, interquartile range
  2. *Numbers do not add up to 2206 because of missing data:11 missing values for tumor stage, 10 missing values for BMI, 7 missing values for alcohol consumption and 2 missing values for smoking status. Complete case analysis was applied when adjusting for these variables
  3. #Leukocyte composition was estimated by Houseman’s method
  4. The proximal colon includes the cecum, the ascending colon and the transverse colon
  5. The distal colon includes the descending colon (the left side of the colon) and the sigmoid colon