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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes

Fig. 3

Interaction of Krebs cycle intermediates and AMPK with DNA methylation. Diagram shows how cytoplasmic glycolysis connects to the Krebs cycle, which occurs in the mitochondria. The latter affects the levels of TETs that are involved in DNA methylation, and which are regulated also by AMPK. AMPK modulates DNA methylation via DNMT directly and indirectly, and by interacting with the Krebs cycle. Different colours refer to the terms metabolic processes (green), DNA processes (purple), metabolites (blue), enzymes (yellow), proteins (red) and miRNA (black)

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