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Fig. 3 | Clinical Epigenetics

Fig. 3

From: High-fat diet-induced and genetically inherited obesity differentially alters DNA methylation profile in the germline of adult male rats

Fig. 3

DNA methylome analysis of spermatozoa from diet-induced and genetically inherited obese groups. ad represent principal component analysis (PCA) plots of DNA methylation profiles. Each colored dot represents a pooled DNA sample for one group. eh Represent whisker box plots for the global methylation of differentially methylated CpGs. il represent volcano plots showing hypermethylated (red circles), hypomethylated (black circles) and neutral (green circles) CpGs. Each circle represents a single CpG site. mp Pie charts representing the regional distribution of differentially methylated CpGs sites obtained in intergenic, exonic, TTS, promoter-TSS and intronic regions in spermatozoa of CD versus HFD, CROb versus WNIN/Ob, LEAN versus WNIN/Ob and LEAN versus CROb groups, respectively

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