Fig. 5

ARHGEF12 and its potential relevance in DLBCL patients and treatment response. a Boxplot of ARHGEF12 grouped by treatment response (PDSD vs PRCR). Log2 transformed of TMM normalized 5hmC enrichment values were plotted, and Wilcoxon t test was used. b Functional protein–protein interaction networks (PPI) from the STRING database. c–h Correlation plots of the mRNA expression of ARHGEF12 with the mRNA expressions of genes in the RHO pathway, including RHOA, RHOB, CDC42, ROCK1, GNA12 and GNA13 in DLBCL in the TCGA-DLBC dataset. i, j Overall survival curves of DLBCL patients with low or high gene expressions in ARHGEF12 or CDC42 in the TCGA-DLBC dataset. The x-axis represents the OS time (days), and the y-axis represents the survival probability. (K) GO enrichment bar plot for genes associated with ARHGEF12 as shown in the PPI network (*p = 0.005–0.05, **p = 0.0005–0.005)