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Table 1 Canonical pathways among total rhesus macaque DMG

From: DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Ingenuity canonical pathways  − log(p value) Genes
Colorectal cancer metastasis signaling 4.42 SRC, LRP5, MMP20, E2F4, GNAS, WNT3, GRB2, AXIN1, PIK3R1, ADCY6, NFKB1, MAPK12, BCL2L1, WNT3A, WNT10A, RND3, ADCY5, MMP26, DCC, TNF, MAP2K1, TCF7L2
Th1 pathway 3.23 STAT4, ITGB2, RUNX3, NOTCH4, HLA-DOA, HLA-DMA, GRB2, LTA, PIK3R1, ICOS, NFATC2, NFKB1, DLL4
Wnt/β-catenin signaling 3.17 UBD, SRC, SOX7, LRP5, CSNK2A1, WNT3A, WNT10A, WNT3, DKK3, AXIN1, RARA, TLE3, MAP4K1, TCF7L2, SOX5
RAR activation 2.65 SRC, CSNK2A1, CYP26A1, SDR16C5, PIK3R1, ADCY6, MAPK12, NFKB1, PRKCZ, PRMT1, ALDH1A3, ADCY5, RARA, CRABP2, MAP2K1
Toll-like receptor signaling 2.44 SIGIRR, UBD, TICAM2, TNFAIP3, MAPK12, NFKB1, TNF, IRAK2
Acute myeloid leukemia signaling 2.40 RUNX1, KITLG, GRB2, PIK3R1, RARA, RPS6KB2, NFKB1, MAP2K1, TCF7L2
Melanocyte development and pigmentation signaling 2.25 KITLG, SRC, GNAS, GRB2, ADCY5, PIK3R1, RPS6KB2, ADCY6, MAP2K1
Role of NFAT in cardiac hypertrophy 2.21 SRC, LIF, HDAC4, GNAS, GRB2, PIK3R1, ADCY6, MAPK12, PRKCZ, ADCY5, IGF1R, CAMK1G, SLC8A1, MAP2K1
GABA receptor signaling 2.12 UBD, SLC6A11, GNAS, AP1G2, ADCY5, ADCY6, GABBR1
Neuregulin signaling 2.01 SRC, NRG2, GRB2, PIK3R1, DCN, RPS6KB2, MAP2K1, PRKCZ
  1. Top 10 pathways sorted by statistical significance are depicted