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Table 1 Canonical pathways among total rhesus macaque DMG

From: DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Ingenuity canonical pathways

 − log(p value)

Genes

Colorectal cancer metastasis signaling

4.42

SRC, LRP5, MMP20, E2F4, GNAS, WNT3, GRB2, AXIN1, PIK3R1, ADCY6, NFKB1, MAPK12, BCL2L1, WNT3A, WNT10A, RND3, ADCY5, MMP26, DCC, TNF, MAP2K1, TCF7L2

Th1 pathway

3.23

STAT4, ITGB2, RUNX3, NOTCH4, HLA-DOA, HLA-DMA, GRB2, LTA, PIK3R1, ICOS, NFATC2, NFKB1, DLL4

Wnt/β-catenin signaling

3.17

UBD, SRC, SOX7, LRP5, CSNK2A1, WNT3A, WNT10A, WNT3, DKK3, AXIN1, RARA, TLE3, MAP4K1, TCF7L2, SOX5

RAR activation

2.65

SRC, CSNK2A1, CYP26A1, SDR16C5, PIK3R1, ADCY6, MAPK12, NFKB1, PRKCZ, PRMT1, ALDH1A3, ADCY5, RARA, CRABP2, MAP2K1

Toll-like receptor signaling

2.44

SIGIRR, UBD, TICAM2, TNFAIP3, MAPK12, NFKB1, TNF, IRAK2

Acute myeloid leukemia signaling

2.40

RUNX1, KITLG, GRB2, PIK3R1, RARA, RPS6KB2, NFKB1, MAP2K1, TCF7L2

Melanocyte development and pigmentation signaling

2.25

KITLG, SRC, GNAS, GRB2, ADCY5, PIK3R1, RPS6KB2, ADCY6, MAP2K1

Role of NFAT in cardiac hypertrophy

2.21

SRC, LIF, HDAC4, GNAS, GRB2, PIK3R1, ADCY6, MAPK12, PRKCZ, ADCY5, IGF1R, CAMK1G, SLC8A1, MAP2K1

GABA receptor signaling

2.12

UBD, SLC6A11, GNAS, AP1G2, ADCY5, ADCY6, GABBR1

Neuregulin signaling

2.01

SRC, NRG2, GRB2, PIK3R1, DCN, RPS6KB2, MAP2K1, PRKCZ

  1. Top 10 pathways sorted by statistical significance are depicted