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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

Fig. 3

Effect of SIV infection on the Th1 pathway using ingenuity pathway analysis. a The canonical Th1 pathway is depicted, with genes within this pathway indicated as symbols and lines indicating regulation. Genes of the canonical Th1 pathway that were differentially methylated (DMG) in MAC are shown in grey; other genes are shown in white. Genes that were differentially expressed (DEG) have a purple border. Some genes were both differentially methylated and differentially expressed following infection (DMG and DEG) and are shown in grey with a purple border. b Heatmaps of gene expression of Th1-related genes during SIV infection. Columns correspond to conditions (species, tissue, phase of infection) and rows to individual genes. The mean log2 fold-changes to baseline are indicated, with blue corresponding to increased expression and yellow to decreased expression. Six AGM (sabaeus) and six Chinese rhesus macaques were analyzed for gene expression during acute (day + 14) and chronic infection (day + 65) from blood, and six and five animals per species were analyzed for acute and chronic infection, respectively, in LN. MB = MAC blood, AB = AGM blood, ML = MAC lymph node, AL = AGM lymph node, A = acute, C = chronic

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