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Fig. 4 | Clinical Epigenetics

Fig. 4

From: 5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers

Fig. 4

HPV(−) tumors have strong hyper-5hmC regions in epithelial and keratinocyte enhancer regions. a HPV(−) HNSCCs showed much higher portion of DhMRs in strong and weak enhancers than both random regions and HPV(+) tumors. Regions were defined using the ChromHMM track for NHEK cells. The number on top indicates the total number of peaks being tested. b Violin plot showing ChIP-seq log(coverage/input) values for top 1000 HPV(+) and top 1000 HPV(−) hyper-5hmC peaks for 9 histone marks. Wilcoxon signed-rank test showed a p value < 10–16 for H3k4me1 peaks. c UCSC Genome Browser view of NHEK strong enhancers near CDH13. Data shown are 5hmC profiles for 6 representative HPV(+) samples (upper 6 tracks) and 6 representative HPV(−) samples (lower 6 tracks), showing 3 regions of high 5hmC level for HPV(−)

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Clinical Epigenetics

ISSN: 1868-7083

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