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Fig. 2 | Clinical Epigenetics

Fig. 2

From: 5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers

Fig. 2

Principle component analysis illustrated sources of heterogeneity in 5hmC levels among HPV(+) HNSCC tumors. a PC2 vs PC3 for proximal promoter regions. b PC1 vs PC2 for custom defined enhancers regions showed clear separation between the IMU subtype and the rest on PC2, which contributed 10.5% and 13.48% of the total variance respectively. c, d PC1 versus PC2 for both proximal promoters and custom defined enhancers showed clear separation by subtype within HPV(+) tumors. e, f The SVD analysis on proximal promoters and enhancers demonstrated several relevant clinical variables, such as survival, percentage of epithelial tissue and subtype, which significantly correlated with each principle component in 18 HPV(+) samples

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