Table 2 Clinical performance of both assays regarding the detection of CIN2+ and CIN3+ in the hrHPV-positive subgroup (n = 149)
From: Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays
True positive | Sensitivity [%] (95% CI) | True negative | Specificity [%] (95% CI) | |
|---|---|---|---|---|
CIN2 + | ||||
GynTect® | 34/60 | 56.7 (43.2–69.4) | 78/89 | 87.6 (79.0–93.7) |
QIAsure Methylation Test | 38/60 | 63.3 (49.9–75.4) | 60/89 | 67.4 (56.7–77.0) |
P value | 0.424 | < 0.001 | ||
CIN3 + | ||||
GynTect® | 28/42 | 66.7 (50.5–80.4) | 90/107 | 84.1 (75.8–90.5) |
QIAsure Methylation Test | 33/42 | 78.6 (63.2–89.7) | 73/107 | 68.2 (58.5–76.9) |
P value | 0.125 | 0.002 | ||