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Table 2 Clinical performance of both assays regarding the detection of CIN2+ and CIN3+ in the hrHPV-positive subgroup (n = 149)

From: Triage of hrHPV-positive women: comparison of two commercial methylation-specific PCR assays

  True positive Sensitivity [%]
(95% CI)
True negative Specificity [%]
(95% CI)
CIN2 + 
 GynTect® 34/60 56.7
(43.2–69.4)
78/89 87.6
(79.0–93.7)
 QIAsure Methylation Test 38/60 63.3
(49.9–75.4)
60/89 67.4
(56.7–77.0)
 P value   0.424    < 0.001
CIN3 + 
 GynTect® 28/42 66.7
(50.5–80.4)
90/107 84.1
(75.8–90.5)
 QIAsure Methylation Test 33/42 78.6
(63.2–89.7)
73/107 68.2
(58.5–76.9)
 value   0.125   0.002