Table 2 Classification and functions of histone deacetylase enzymes
From: Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma
HDAC classification | Subtypes | Location | Function/role |
|---|---|---|---|
Class I | HDAC1, HDAC2, HDAC3, HDAC8 | Nucleus | Participate in the regulation of histone deacetylation modification |
Class II | IIAHDACs (HDAC4, HDAC5, HDAC7, HDAC9) | Shuttle between cytoplasm and nucleus | In response to mitogenic signals [165] |
| Â | IIb-HDACs (HDAC6 HDAC10) | Cytoplasm | HDAC6 is reported to modulate the function of the non-histone protein HSP90 [166] |
Class III [167] | Seven members of this family are SIRT1 through SIRT7 | SIRTs are located in cellular compartments: nucleus, cytoplasm, and mitochondrion | Involved in cell ageing and energy metabolism processes [168,169,170] |
Class IV | HDAC11 | nucleus | Implicate in the regulation of interleukin-10 expression [171, 172] |