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Table 2 Classification and functions of histone deacetylase enzymes

From: Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma

HDAC classification Subtypes Location Function/role
Class I HDAC1,
HDAC2,
HDAC3,
HDAC8
Nucleus Participate in the regulation of histone deacetylation modification
Class II IIAHDACs (HDAC4, HDAC5, HDAC7, HDAC9) Shuttle between cytoplasm and nucleus In response to mitogenic signals [165]
  IIb-HDACs (HDAC6 HDAC10) Cytoplasm HDAC6 is reported to modulate the function of the non-histone protein HSP90 [166]
Class III [167] Seven members of this family are SIRT1 through SIRT7 SIRTs are located in cellular compartments: nucleus, cytoplasm, and mitochondrion Involved in cell ageing and energy metabolism processes [168,169,170]
Class IV HDAC11 nucleus Implicate in the regulation of interleukin-10 expression [171, 172]