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Table 6 Top hypo-methylated (5 of 43) and hyper-methylated (5 of 41) individual cytosines associated with gene bodies (exons/introns)

From: Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions

Gene ID Control % Patient % Difference P value Q value
MEGF6 55 17 − 38 1.12 × 10–11 4.63 × 10–9
CD6 41 3 − 38 1.90 × 10–16 1.02 × 10–13
KIF1A 50 14 − 36 1.83 × 10–10 7.16 × 10–8
MEGF11 84 52 − 32 6.09 × 10–12 2.54 × 10–9
TMCO3 94 61 − 33 3.28 × 10–9 1.20 × 10–6
LINC00664 53 95 + 42 2.95 × 10–15 1.50 × 10–12
LOC642423 43 84 + 41 2.60 × 10–14 1.24 × 10–11
KCNK10 54 93 + 39 2.92 × 10–17 1.60 × 10–14
IDUA 59 95 + 36 1.21 × 10–13 5.58 × 10–11
FAM182B 0 34 + 34 8.99 × 10–16 4.71 × 10–13
  1. Gene-associated cytosine significance values were calculated using a Fisher’s test. For each cytosine, there is also corresponding genomic location, the average methylation percentages for the control subjects and ME/CFS patients, with differences (− hypo-methylated, + is hyper-methylated). Corresponding P and Q values are indicated. The full dataset is available in Additional file 1: Excel file ‘MethylKit_Gene_Full’