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Table 5 Top hypo-methylated (5 out of 17) and top hyper-methylated (5 out of 14) methylated fragment-associated gene bodies (exons/introns)

From: Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions

Gene ID CpGs Control % Patient % Difference P value F test value
SARDH 3 88 64 − 24 6.52 × 10–3 F(1,14) = 10.19
MAST4 4 82 61 − 21 4.72 × 10–3 F(1,14) = 11.26
GRAMD4 4 64 44 − 20 4.80 × 10–2 F(1,13) = 4.76
GNG7 7 64 45 − 19 2.94 × 10–2 F(1,17) = 5.66
RP11-566K11.2 7 46 28 − 18 6.01 × 10–2 F(1,15) = 18.70
ZNF714 6 12 42 + 30 1.12 × 10–2 F(1,16) = 8.22
DNAJB13 5 41 69 + 28 4.57 × 10–4 F(1,15) = 19.91
COX19 6 11 32 + 21 1.96 × 10–2 F(1,15) = 6.82
CARD8 3 77 98 + 21 7.06 × 10–4 F(1,13) = 19.44
C8orf31 9 43 64 + 21 4.75 × 10–2 F(1,13) = 4.79
  1. For each gene, the number of CpGs within the fragment, and methylation percentages of control subjects and ME/CFS patients are shown, with the differences (− is hypo-methylated, + is hyper-methylated). Significance scores are shown as P values and corresponding F value (degrees of freedom in brackets). A full list is available in Additional file 1: Excel file ‘DMAP_Gene_Full’.