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Table 4 Genes linked to promoter regions associated with the top differentially methylated individual cytosines (5 of 31 hypo- and 5 of 14 hyper-methylated)

From: Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions

Gene ID Control % Patient % Difference P value Q value
LOC339166 76 34 − 42 3.94 × 10–12 1.67 × 10–9
LOC339166 74 32 − 40 1.96 × 10–11 7.97 × 10–9
LOC339166 75 35 − 39 9.19 × 10–11 3.63 × 10–8
LOC339166 71 35 − 35 4.71 × 10–9 1.70 × 10–6
LOC339166 75 39 − 35 8.62 × 10–9 3.05 × 10–6
FANK1 19 48 + 28 2.31 × 10–12 9.82 × 10–10
CILP2 30 51 + 23 1.94 × 10–4 3.40 × 10–2
A2M-AS1 13 32 + 21 4.93 × 10–5 1.05 × 10–2
SPIN2B 20 40 + 20 2.45 × 10–5 5.58 × 10–3
MT1M 12 29 + 18 1.21 × 10–4 2.29 × 10–2
  1. For each Gene ID, there is the corresponding average percentage methylation for the control subjects and ME/CFS patients, with the differences shown (− is hypo-methylated, + is hyper-methylated). P and Q values are indicated. The full dataset is available in Additional file 1: Excel file ‘MethylKit_Promoter_Full’