Table 2 Genes linked to regulatory features overlapping with clusters of differential methylation
Gene ID | Regulatory element | Cluster | Description |
|---|---|---|---|
XAF1 | GH17J005769 | CHR17 | A negative regulator of the inhibitor of apoptosis (IAP) family resulting in increased stress induced apoptosis |
ZNF594 | GH17J005769 | CHR17 | Implicated in transcriptional regulation |
DUSP22 | GH06J000290 + Region of enhancer (GH06J000290) and gene interaction | CHR6 | Activator of the JnK pathway involved in apoptosis, inflammation, cytokine production and metabolism |
EXOC2 | GH06J000290 | CHR6 | A component of the exocyst complex important for the targeting of vesicles to docking sites on the plasma membrane |
IRF4 | GH06J000290 + Region of enhancer (GH06J000225) and gene interaction | CHR6 | A lymphocyte specific member of the interferon regulatory factor family of transcription factors for regulation of interferons in response to infection by virus |
UCP2 | Region of enhancer (GH11J073778) and gene interaction | CHR11 | A member of the mitochondrial uncoupling protein family that creates proton leaks across the inner mitochondrial membrane |
DNAJB13 | Region of enhancer (GH11J073968) and gene interaction | CHR11 | A heat shock protein with an important role in the formation of the central complex of ciliary and flagellar axonemes |
DUS3L | Gene Body Overlap + GH19J005798 + Region of enhancer (GH19J006270) and gene interaction | CHR19 | A protein catalyzing the synthesis of dihydrouridine |
LONP1 | GH19J005798 | CHR19 | A mitochondrial matrix protein that mediates the selective degradation of damage and the regulation of mitochondrial gene expression |
CATSPERD | GH19J005798 | CHR19 | A component of the CatSper complex involved in sperm cell hyperactivation |
FUT6 | GH19J005798 | CHR19 | A Golgi stack membrane protein involved in the creation of the blood group antigen sialyl-Lewis X |
FUT3 | GH19J005798 | CHR19 | An enzyme that catalyzes the final step of Lewis antigen biosynthesis involved in the expression of; Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewix X/SSEA-1 antigens |
FUT5 | GH19J005798 | CHR19 | A paralog of FUT6 |
NDUFA11 | GH19J005798 | CHR19 | A subunit of the membrane bound mitochondrial complex I which functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain |
VMAC | GH19J005798 + Region of enhancer (GH19J005620) and gene interaction | CHR19 | A vimentin-type intermediate filament-associated coiled-coil protein |
NRTN | GH19J005798 + Region of enhancer (GH19J005798) and gene interaction | CHR19 | A member of the GDNF family for survival and function of neurons. Implicated in immune responses with PBMCs—up-regulation indicating immune cells are communicating via NRTN |
SAFB | Region of enhancer (GH19J006055) and gene interaction | CHR19 | Implicated with stress responses, cell cycle, apoptosis and cell differentiation |