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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions

Fig. 2

Pie charts showing proportional locations of differential methylation between patients and controls. a Genomic location of the differentially methylated fragments (DMFs) and b genomic location of the differentially methylated CpGs or DMCs. The differential methylation was mapped to annotated human genome data including; (1) exons (brown), (2) intergenic regions (blue), (3) introns (red) and (4) promoter regions (defined as 1500 bp upstream and 500 bp downstream from the TSS) (green). Proportions of hypo-methylated sites/fragments are indicated by the darker ‘solid’ coloured segments, and hyper-methylated proportions by the lighter ‘shaded’ segments. ‘−’ is hypo-methylated, and ‘+’ is hyper-methylated. The percentages in each segment are shown

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