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Table 1 Characteristics of the study participants

From: DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

 

KORA F4 (N = 1662)

LOLIPOP (N = 2805)

YFS (N = 176)

NFBC1966 (N = 771)

Age (years)

61.0 (8.9)

51.4 (10.1)

44.2 (3.3)

31.0 (0.3)

Sex = male

49.0%

68.0%

37.5%

43.7%

BMI (kg/m2)a

28.1 (4.8)

27.7 (4.4)

25.9 (4.5)

24.4 (3.7)

Current smokers

14.4%

8.9%

16.5%

26.2%

Ex-smokers

41.5%

8.7%

25.6%

19.2%

Never smokers

44.1%

82.4%

58.0%

53.3%

Alcohol consumption (g/day)

15.5 (20.3)

6.38 (14.2)

0.716 (0.9)b

8.7 (14.3)

C-reactive protein (mg/l)

2.5 (5.2)

4.2 (7.2)

1.4 (2.4)

1.85 (3.3)

HDL-C (mmol/l)

1.7 (0.4)

1.3 (0.3)

1.7 (0.4)

1.7 (0.5)

LDL-C (mmol/l)

2.1 (0.6)

1.9 (0.6)

2.1 (0.6)

2.0 (0.7)

Total cholesterol (mmol/l)

5.7 (1.0)

4.9 (1.1)

5.3 (1.0)

5.5 (1.4)

Total TGc (mmol/l)

1.6 (0.8)

1.5 (0.7)

1.2 (0.6)

1.2 (0.7)

VLDL-TG (mmol/l)

1.1 (0.8)

0.9 (0.6)

0.7 (0.6)

0.7 (0.5)

Total FA (mmol/l)

14.5 (2.4)

12.5 (3.0)

12.9 (2.3)

13.4 (3.5)

Hypertensione

45.5%

38.0%

19.3%

16.7%

Hospitalized myocardial infarctione

3.6%

3.9%

0.0%

0.0%

Intake of lipid-lowering drugs

16.2%

NAd

4.0%

0.0%

  1. Displayed are characteristics of the discovery (KORA F4) and replication studies. Continuous and categorical characteristics are given as mean (standard deviation) for continuous variables and proportions for categorical variables. For every characteristic the p value for a difference between studies is < 0.001, given by a one-way ANOVA for continuous variables, and the Chi-square test for categorical variables
  2. aBMI: body mass index
  3. bDrinks per day (directly proportional to g/day)
  4. cTG: triglycerides
  5. dNA: variable not available
  6. eSelf-reported history