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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Longitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging

Fig. 2

Functional analysis of dmCpGs. a Number of U- and Nu-dmCpGs at promoters, enhancers and weak-transcripts (top), promoters with and without CpG Island (CGI) (bottom). P values by fisher’s test. b Percentage (%) methylation change (t2 vs. t1) on U- and Nu-dmCpGs associated genes that are TSGs (black) or oncogenes (white) and are epigenetic regulators. c Pathways enriched in U- and Nu-dmCpGs (hyper and hypo) associated-genes found in proximal and distal colon. Venn diagram shows overlap of pathways (13 unique in users, 10 unique in nonusers, 7 common), and heatmaps illustrate the significance of enrichment (adj. P values < 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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