Table 3 Association of SDC2 methylation with clinicopathological features of CRC
Variable | Colonoscopy (N = 359) no | Stool DNA test positive (N = 301) no. (n/N, %) | Stool DNA test negative (N = 58) no. (n/N, %) | P value* |
|---|---|---|---|---|
Gender | ||||
Male | 234 | 203 (86.8) | 31 (13.2) | 0.041# |
Female | 125 | 98 (78.4) | 27 (21.6) | |
Age | ||||
≦ 49 | 83 | 66 (79.5) | 17 (20.5) | 0.500 |
50–59 | 104 | 86 (82.7) | 18 (17.3) | |
60–69 | 111 | 97 (87.4) | 14 (12.6) | |
≧ 70 | 61 | 52 (85.2) | 9 (14.8) | |
TNM stage | ||||
I | 46 | 40 (87.0) | 6 (13.0) | 0.323 |
II | 108 | 94 (87.0) | 14 (13.0) | |
III | 160 | 133 (83.1) | 27 (16.9) | |
IV | 45 | 34 (75.6) | 11 (24.4) | |
Location 1 | ||||
Proximal | 50 | 38 (76.0) | 12 (24.0) | 0.104 |
Distal | 309 | 263 (85.1) | 46 (14.9) | |
Location 2 | ||||
Colon | 127 | 100 (78.7) | 27 (21.3) | 0.052 |
Rectum | 232 | 201 (86.6) | 31 (13.4) | |
Differentiation | ||||
Well | 44 | 38 (86.4) | 6 (13.6) | 0.641 |
Moderate | 257 | 213 (82.9) | 44 (17.1) | |
Poor | 27 | 24 (88.9) | 3 (11.1) | |