Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study

Table 2 Performance characteristics of the sDNA test for the detection of colorectal neoplasia

Category	Colonoscopy (N = 1110) no	Stool DNA test (N = 1110)
Category	Colonoscopy (N = 1110) no	Positive (n = 331) no	Sensitivity (95% CI) %	Kappa (95% CI)
Colorectal cancer
Any	359	301	83.8 (79.5–87.4)	0.84 (0.81–0.88)
Stage I–II	154	134	87.0 (80.4–91.7)	0.86 (0.82–0.90)
Advanced adenoma	38	16	42.1 (26.7–59.1)	0.45 (0.28–0.59)
Advanced colorectal neoplasia^a	397	317	79.9 (75.5–83.6)	0.81 (0.76–0.85)

			Specificity (95% CI)
Normal^b	713	14	98.0 (96.6–98.9)	N/A

^aAdvanced colorectal neoplasia includes colorectal cancer and advanced adenoma
^bNonadvanced colorectal neoplasia, non-neoplastic findings and negative results on colonoscopy

ISSN: 1868-7083