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Fig. 4: | Clinical Epigenetics

Fig. 4:

From: DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Fig. 4:

5hmC is dynamic and heterogeneous in MM between diagnosis and relapse. a MS quantification of 5hmC at diagnosis and relapse in patients MM02, MM05, MM07 and MM21 (average shown). b Plot showing the differential 5hmC-enriched domains between diagnosis and relapse in patients MM02, MM05, MM07 and MM21. c 5hmC signal and RNA expression levels of the MDM2 gene at diagnosis and relapse in patient MM05. At relapse, myeloma cells harbor one copy of TP53 locus (del17p FISH)

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Clinical Epigenetics

ISSN: 1868-7083

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