Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

Clinical Epigenetics

Table 3 Associations between early life rapid growth and childhood methylation in the replication cohort (SWS children age 11–13, n = 104)

Exposure	CpG site	Nearest gene	ISVA			SVA
Exposure	CpG site	Nearest gene	Coef	SE	P	Coef	SE	P
Models with cell counts
RWG	cg11531579	CHFR	0.0045	0.0020	0.02	0.0045	0.0021	0.04
RWG	cg01379158	NT5M	0.0004	0.0029	0.90	− 0.0022	0.0026	0.40
RT	cg11531579	CHFR	0.0022	0.0026	0.39	0.0029	0.0024	0.23
RT	cg01379158	NT5M	− 0.0002	0.0036	0.96	− 0.0030	0.0029	0.31
Models without cell counts
RWG	cg11531579	CHFR	0.0005	0.0020	0.82	− 0.0002	0.0020	0.92
RWG	cg01379158	NT5M	0.0019	0.0023	0.40	0.0020	0.0023	0.40
RT	cg11531579	CHFR	− 0.0013	0.0020	0.52	− 0.0020	0.0022	0.37
RT	cg01379158	NT5M	0.0043	0.0027	0.12	0.0018	0.0026	0.48

P, unadjusted p value, Coef, coefficient; SE, standard error; RWG, rapid weight gain; RT, rapid thrive; SVA, Surrogate variable analysis, and ISVA, independent surrogate variable analysis

ISSN: 1868-7083