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Table 3 Associations between early life rapid growth and childhood methylation in the replication cohort (SWS children age 11–13, n = 104)

From: Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight

Exposure CpG site Nearest gene ISVA SVA
Coef SE P Coef SE P
Models with cell counts
RWG cg11531579 CHFR 0.0045 0.0020 0.02 0.0045 0.0021 0.04
RWG cg01379158 NT5M 0.0004 0.0029 0.90 − 0.0022 0.0026 0.40
RT cg11531579 CHFR 0.0022 0.0026 0.39 0.0029 0.0024 0.23
RT cg01379158 NT5M − 0.0002 0.0036 0.96 − 0.0030 0.0029 0.31
Models without cell counts
RWG cg11531579 CHFR 0.0005 0.0020 0.82 − 0.0002 0.0020 0.92
RWG cg01379158 NT5M 0.0019 0.0023 0.40 0.0020 0.0023 0.40
RT cg11531579 CHFR − 0.0013 0.0020 0.52 − 0.0020 0.0022 0.37
RT cg01379158 NT5M 0.0043 0.0027 0.12 0.0018 0.0026 0.48
  1. P, unadjusted p value, Coef, coefficient; SE, standard error; RWG, rapid weight gain; RT, rapid thrive; SVA, Surrogate variable analysis, and ISVA, independent surrogate variable analysis